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glial cell line-derived neurotrophic factor

   Also found in: Wikipedia 0.01 sec.
glial cell line-derived neurotrophic factor (GDNF)
[glī′əl]
a nerve growth drug that has been used in laboratory animals to reverse the progression of symptoms of Parkinson's disease and other brain diseases. GDNF is believed to act as a biologic shield, protecting nerve cells from damage that normally would destroy them.


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Called Glial Cell Line-Derived Neurotrophic Factor, or GDNF, the drug has been shown to reverse Parkinson's disease symptoms in preclinical trials.
Amgen (Nasdaq:AMGN), the world's largest biotechnology company, today announced that the Phase 2 study of its novel glial cell line-derived neurotrophic factor, or GDNF, for the treatment of advanced Parkinson's disease did not meet the primary study endpoint upon completion of six months of the double-blind treatment phase of the study.
 
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