Gleason score

(redirected from Gleason system)

Glea·son tu·mor grade

a classification of adenocarcinoma of the prostate by evaluation of the pattern of glandular differentiation; the tumor grade, known as Gleason score, is the sum of the dominant and secondary patterns, each numbered on a scale of 1 to 5.

Gleason score

Oncology A value derived from the Gleason grading system which is the sum of the 2 most predominant histologic patterns seen in prostate CA.

Gleason score

A method of grading malignancy of prostate cancers, based on the pattern of glandular differentiation. Both the dominant and secondary patterns of differentiation are scored on a scale of 1 to 5, and the Gleason score, is the sum of the two scores.


Donald F., U.S. pathologist, 1920–.
Gleason score
Gleason tumor grade - a classification of adenocarcinoma of the prostate.
References in periodicals archive ?
It is recommended now to report both the new prognostic grouping system and the Gleason system together, until it becomes widely accepted and practiced.
After examining the haematoxylin and eosin stained slides, the tumours were classified according to modified Gleason system with ISUP recommendations.
The concept of grouping components of the Gleason system is hardly novel and, in fact, was proposed by Gleason himself in 1977.
5,6) Moreover, the differences between the original Gleason system and the 2005 ISUP Modified Gleason System make it difficult to compare data sets assessing patient outcomes in prostate cancer over time.
At McCaffrey's, a three-store New Jersey independent that has had the system for six years, managers use the Gleason system for hourly store walk-throughs.
The most critical threshold in the Gleason system is in the recognition of patterns 4 and 5.
A major point of divergence from the original Gleason system is with the assignment of grade to cribriform glands.
In addition, a cribriform pattern is usually grade 4 in the ISUP 2005 modified Gleason score system, rather than grade 3 or grade 4, as in the classic Gleason system.
By 1974, Gleason and the Veterans Administration Cooperative Urological Research Group expanded their study of the original Gleason system to 1032 men.
Of the many proposed systems over time for the grading of prostate cancer, currently the most widely accepted and used is the Gleason system.