Gleason score

(redirected from Gleason system)

Glea·son tu·mor grade

a classification of adenocarcinoma of the prostate by evaluation of the pattern of glandular differentiation; the tumor grade, known as Gleason score, is the sum of the dominant and secondary patterns, each numbered on a scale of 1 to 5.

Gleason score

Oncology A value derived from the Gleason grading system which is the sum of the 2 most predominant histologic patterns seen in prostate CA.

Gleason score

A method of grading malignancy of prostate cancers, based on the pattern of glandular differentiation. Both the dominant and secondary patterns of differentiation are scored on a scale of 1 to 5, and the Gleason score, is the sum of the two scores.


Donald F., U.S. pathologist, 1920–.
Gleason score
Gleason tumor grade - a classification of adenocarcinoma of the prostate.
References in periodicals archive ?
Further issues relating to radical prostatectomy specimens, such as the grading of multiple nodules within the same prostate, determining variants and variations of PCa, or dealing with tertiary patterns, were not addressed within the original Gleason system.
The Gleason system also predated the use of immunohistochemistry.
Forty Years After the Inception of the Gleason System
Nearly 40 years after its inception, the Gleason system remains one of the most powerful prognostic factors in PCa.
The most critical threshold in the Gleason system is in the recognition of patterns 4 and 5.
Of the many proposed systems over time for the grading of prostate cancer, currently the most widely accepted and used is the Gleason system.
A major departure from the original Gleason system is that most cribriform carcinomas (>95%) are in fact considered Gleason pattern 4 or pattern 5 (with comedonecrosis) carcinomas, with only rare cribriform lesions satisfying diagnostic criteria for cribriform pattern 3, as described earlier.
Readers are referred to the recommendations of a recent consensus conference dealing with the contemporary usage of the Gleason system.
Two systems continue to be applied, namely, the Gleason system and the World Health Organization system.
Lack of understanding of and experience with Gleason system