Gleason grading system

Gleason grading system

Oncology The most widely used system for stratifying the histologic features of prostate CA, delineated by Gleason, dividing the lesions into 5 groups of ↓ glandular differentiation and worsening prognosis

Gleason grading system

A method of predicting the tendency of a tumor in the prostate to metastasize based on how similar the tumor is to normal prostate tissue.
Mentioned in: Prostate Cancer
References in periodicals archive ?
Title: Clinical validation of the 2005 ISUP Gleason grading system in a case-cohort of intermediate and high risk men undergoing radical prostatectomy Abstract Number: MP53-17
Upgrading and downgrading of prostate cancer from biopsy to radical prostatectomy: Incidence and predictive factors using the modified Gleason grading system and factoring in tertiary grades.
The prognostic significance of tertiary Gleason patterns of higher grade in radical prostatectomy specimens: a proposal to modify the Gleason grading system.
Tomaszewski: The Gleason grading system is the most powerful grading tool for the prediction of outcome amongst all the tumor systems.
By doing so, we will elucidate how recent events - specifically, the advent of active surveillance and the update in the Gleason grading system - have influenced the discordance rates over time.
Since its establishment in 1966, the Gleason grading system for prostatic adenocarcinoma has undergone several modifications to enhance the correlation between histologic findings and clinical outcome.
To understand the negative value of tumour upgrade and the impact on correct treatment selection and prognostic evaluation, the Gleason grading system for prostatic carcinoma underwent its first major revision at the International Society of Urological Pathology (ISUP) consensus conference in 2005.
The Gleason grading system of prostatic carcinoma is the quintessential prognostic factor in predicting findings in radical prostatectomy, biochemical failure, local recurrences, and lymph node or distant metastasis in patients receiving no treatment, radiation therapy, radical prostatectomy, and other therapies, including cryotherapy and high-intensity focal ultrasound therapy.
The Gleason grading system is one of the most important means to predict and choose treatment for men with prostate cancer.
In particular, the recommendations regarding pattern interpretation and reporting are summarized and discussed, the practical consequences of the ISUP modification of the Gleason grading system are described, and the prognostic importance of the Gleason score, its reproducibility, and preoperative assessment are explained.