glatiramer

glatiramer

 [glah-tir´ah-mer]
an immunomodulator used as the acetate ester to reduce relapses in multiple sclerosis; administered by subcutaneous injection.

glatiramer

/gla·tir·a·mer/ (glah-tir´ah-mer) an immunomodulator used as the acetate ester to reduce relapses in multiple sclerosis.

glatiramer

a multiple sclerosis drug.
indication It is used to reduce the frequency of relapses in patients with relapsing-remitting multiple sclerosis.
contraindications Known hypersensitivity to this drug or to mannitol prohibits its use.
adverse effects Adverse effects include migraine, palpitations, syncope, tachycardia, vasodilation, nausea, vomiting, diarrhea, anorexia, gastroenteritis, ecchymosis, lymphadenopathy, edema, weight gain, arthralgia, anxiety, hypertonia, tremor, vertigo, speech disorder, agitation, confusion, bronchitis, dyspnea, pruritus, rash, sweating, urticaria, erythema, ear pain, urinary urgency, dysmenorrhea, and vaginal moniliasis.

glatiramer

A mixture of synthetic polypeptides that act on the immune system and are claimed to reduce substantially the frequency of relapses in people with relapsing MULTIPLE SCLEROSIS. Its use is restricted to those who have suffered a relapse in the previous two years. The drug is unsuitable for patients who are severely affected and unable to get about unaided. A brand name is Copaxone.
References in periodicals archive ?
The patent relates to methods for the treatment of multiple sclerosis through the administration of at least three 40 mg/mL subcutaneous injections of glatiramer acetate per week.
Generic glatiramer acetate is equivalent to copaxone on efficacy and safety: results of the randomized double-blind GATE trial in multiple sclerosis, J.
On quality of life measures, monotherapy and combination therapy proved largely equal--and equally well tolerated--in the "CombiRx" study, in which half of the patients got the combination and a quarter got either glatiramer acetate (Copaxone) or interferon beta-la (Avonex) alone plus a placebo.
Ilk basamak tedavi secenegi olan interferonlarin (interferon-beta1a, interferon-beta-1b) ve glatiramer asetatin (GA, Copolymer 1) olusturdugu bu grup tedavilerin atak sikligi ve hastalik progresyonu uzerine olumlu etkisi bulunmaktadir (2,5).
The drug can be given to patients whose condition is not being controlled by self-administered injections of beta interferon or glatiramer acetate.
Khoury, of Brigham and Women's Hospital and Harvard Medical School, Boston, and colleagues assessed the effects of albuterol treatment as an add-on therapy for patients starting treatment with glatiramer acetate, currently approved as a therapy for relapsing-remitting MS.
Glatiramer acetate significantly delayed the conversion of clinically isolated syndrome to clinically definite multiple sclerosis, according to a randomized, double-blind, placebo-controlled trial published in the Lancet.
Patients with multiple sclerosis often use injectable medication such as glatiramer acetate or interferons to treat their disease.
Copaxone, known chemically as glatiramer acetate, "reduced the frequency of relapses in the short term and might reduce the rate of accumulation of irreversible disability in the long term," wrote researchers led by Giancarlo Comi, a professor in the department of neurology at University Vita-Salute in Milan.
The drug, glatiramer acetate, cut the chance of patients getting a confirmed diagnosis of MS by almost half over a three-year period.
Summary: TEHRAN (FNA)- A new study for comparing the efficacy of 250 micro/g or 500 micro/g interferon beta-1b with Glatiramer acetate for treating relapsing-remitting multiple sclerosis showed that both doses had similar clinical effects to Glatiramer acetate.
HONOLULU -- A study of 345 pregnancies occurring in women taking glatiramer acetate for multiple sclerosis suggested that use of the drug results in no increased risk of adverse fetal or pregnancy outcomes.