ginkgolides

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ginkgolides

Alternative pharmacology
A large group of medicinal preparations from a tree in northern China, Ginkgo biloba, which are used by herbalists for cardiovascular and cerebrovascular disease, emotional lability, ocular defects, panic disorder, vertigo and other conditions.
References in periodicals archive ?
Protective effects of Ginkgo biloba extract (EGb761) and its constituents quercetin and ginkgolide B against beta-amyloid peptide-induced toxicity in SH-SY5Y cells.
PAF receptor antagonist Ginkgolide B inhibits tumourigenesis and angiogenesis in colitis-associated cancer.
Bilobalide, ginkgolide A, ginkgolide B, and terpenes are thought to be the major active compounds in GBE that improve memory (Shah et al.
Neuroprotective Effect of Ginkgolide K against H2O2-Induced PC12 Cell Cytotoxicity by Ameliorating Mitochondrial Dysfunction and Oxidative Stress," Ma et al, Biological and Pharmaceutical Bulletin Vol.
eCoMFA, CoMSIA, and HQSAR, were used to investigate the relationship between 117 ginkgolide analogues and their bioactivities against PAF receptor.
In contrast, relatively few natural products bearing the t-Bu substructure have been structurally determined, yet representative examples of these natural products, such as ginkgolide A, apratoxin A and polytheonamide B, were demonstrated to exhibit potent and selective biological activities.
In vitro suppression of lymphocyte activation in patients with seasonal allergic rhinitis and pollen-related asthma by cetirizine or azelastine in combination with ginkgolide B or astaxanthin.
Ginkgolide B is widely reported to be a potent platelet activating factor antagonist (anti PAF) (Ahlemeyer 2003, Oken 1998, Smith 1996).
Ginkgo biloba is one of the three main ingredients in TRF; it has three components whose mechanisms of action reduce tinnitus: (1) flavonol glycosides, responsible for ginkgo's antioxidant actions; (2) ginkgolide fractions of terpene lactones, which support blood vessel relaxation and inhibit platelet activating factor, resulting in increased circulation, especially in the micro-capillaries that feed the brain, eyes, and ears; and (3) the bilobalide fraction of terpene lactones, which protects brain neurons by affecting gamma-aminobutyric acid receptors in the brain and by glutamate antagonism and antioxidant activity.
The method by which GBE can stabilize this has not been completely elucidated, but bilobalide and ginkgolide A are thought to have a role in this process.
Ex vivo regulation of adrenal cortical cell steroid and protein synthesis, in response to adrenocorticotropic hormone stimulation, by the ginkgo biloba extract EGb 761 and isolated ginkgolide B.
The mechanism of action of ginkgo is believed to be produced by its functions as neuroprotective agent, antioxidant, free-radical scavenger, membrane stabilizer, and inhibitor of platelet activating factor via the terpene ginkgolide B.