ginkgolides

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ginkgolides

Alternative pharmacology
A large group of medicinal preparations from a tree in northern China, Ginkgo biloba, which are used by herbalists for cardiovascular and cerebrovascular disease, emotional lability, ocular defects, panic disorder, vertigo and other conditions.
References in periodicals archive ?
EGb 761 was assayed to include 24% of Ginkgo flavone glycosides, mainly kaempferol and quercetin glucorhamnoside esters, and 6% of the characteristic terpene lactones, the bilobalide and ginkgolides, namely, A, B, C and very small quantities of ginkgolide J.
Dosage effects of ginkgolide B on ethanol-induced cell death in human hepatoma G2 cells.
Ginkgolide B complex efficacy for brief prophylaxis of migraine in school-aged children: an open-label study.
Protective effects of Ginkgo biloba extract (EGb761) and its constituents quercetin and ginkgolide B against beta-amyloid peptide-induced toxicity in SH-SY5Y cells.
eCoMFA, CoMSIA, and HQSAR, were used to investigate the relationship between 117 ginkgolide analogues and their bioactivities against PAF receptor.
Ginkgolide B is widely reported to be a potent platelet activating factor antagonist (anti PAF) (Ahlemeyer 2003, Oken 1998, Smith 1996).
Ginkgo biloba is one of the three main ingredients in TRF; it has three components whose mechanisms of action reduce tinnitus: (1) flavonol glycosides, responsible for ginkgo's antioxidant actions; (2) ginkgolide fractions of terpene lactones, which support blood vessel relaxation and inhibit platelet activating factor, resulting in increased circulation, especially in the micro-capillaries that feed the brain, eyes, and ears; and (3) the bilobalide fraction of terpene lactones, which protects brain neurons by affecting gamma-aminobutyric acid receptors in the brain and by glutamate antagonism and antioxidant activity.
The method by which GBE can stabilize this has not been completely elucidated, but bilobalide and ginkgolide A are thought to have a role in this process.
Ex vivo regulation of adrenal cortical cell steroid and protein synthesis, in response to adrenocorticotropic hormone stimulation, by the ginkgo biloba extract EGb 761 and isolated ginkgolide B.
Other topics include the distribution of selenium and zinc, monocyte survival through defines intracellular pathways, insulin expression in rat testes and a new transcript splice variant of the human glacocorticoid receptor, while chemoprevention topics include the effects of wagonin, ginkgolide B, and phenolic phytochemicals.
Ginkgolide B, a component of Ginkgo biloba, is a known platelet aggregation factor antagonist, and the herb, alone or with analgesics, has been associated with intracranial bleeding events.