Drug induced gingival overgrowth starts as a bead like fibrotic generalized papillary enlargement & involves the attached gingiva in later stages.
2,3) Oral prophylaxis alone will not be sufficient to control the fibrotic gingival overgrowth, but even surgical excision of hyperplastic tissues is essential.
Moreover, the esthetic disfigurement & the functional impairment resulting from severe gingival overgrowth can have a negative impact in the physical social & emotional well--being of the patient.
i) Combination hypothesis--Combination of several factors like the drug intake, periodontal status & tooth--sulcular epithelial integrity is also responsible for gingival overgrowth.
One might also expect to find increased numbers of these cells or increased amounts of these growth factors in conditions which involve increased tissue volume such as drug induced gingival overgrowth.
Taken together, the data from these experiments constitute an important first step in determining if inducing apoptosis could be a viable, nonsurgical method of managing cellular proliferative disorders like drug-induced gingival overgrowth.
Gingival overgrowth is an undesirable and well recognized side-effect of oral, intramuscular, or intravenous use of various drugs, including phenytoin, phenobarbital, valproate, nifedipine, verapamil and cyclosporine (Beveridge et al.
Cyclosporin A-induced gingival overgrowth in renal transplant patients.
Mechanisms and management of gingival overgrowth in paediatric transplant recipients: A review.
However, there was generalised gingival overgrowth, as the result of Epilim and Nifedipine medication (Fig 1a, 1b).
As the patients plaque control was good, there were no signs of gingivitis and the gingival overgrowth was stable and not progressive, chlorhexidine mouthwash or gel was not indicated.
Watch for the effects of medications that cause dry mouth and gingival overgrowth