Giant Metamyelocyte

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Giant Metamyelocyte

An atypical myeloid cell with clumped chromatin in a large, often bizarre, immature nucleus, and relatively mature cytoplasm. Giant metamyelocytes are typical of megaloblastic anemia (due to a vitamin B12 and/or folic acid deficiency), as nuclei cannot properly mature without single-carbon transport which is largely dependent on vitamin B12 and folic acid

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