ghrelin

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ghrel·in

(grel'in),
A naturally occurring 28-amino acid gut-brain growth hormone releasing peptide (GHRP) that is expressed mainly in the stomach and possibly in the hypothalamus. Fasting and hypoglycemia increase ghrelin levels and circulating ghrelin levels are decreased in chronic obesity, following acute caloric intake and in states of positive energy balance. Acute administration of ghrelin to humans induces a feeling of hunger. Ghrelin binds to ghrelin-receptors in the anterior pituitary and possibly in the mediobasal and mediolateral hypothalamus to stimulate growth hormone release and to regulate energy homeostasis. Serum levels of ghrelin are measurably higher in patients who have lost weight through dietary measures.
[growth hormone release + -in]

ghrelin

(grĕl′ən)
n.
A hormone that is secreted by cells in the stomach and promotes hunger before an expected meal, decreases in amount after eating, and promotes secretion of growth hormone.

ghrel·in

(grel'in)
A peptide hormone secreted by endocrine cells in the gastrointestinal tract. Acts as a growth hormone secretagogue and as an orexigenic agent mediated by the hypothalamic hormones neuropeptide Y (NPY) and agouti growth-related peptide (AGRP).
[growth hormone release + -in]

ghrelin

A 28-amino acid peptide hormone that stimulates release of growth hormone from the anterior pituitary and has significant effects on appetite and energy balance. The main source of ghrelin is the epithelial cells of the fundus of the empty stomach. Recent studies have shown that, in mice, the hormone also interacts with the hippocampus and appears to improve memory and cognitive function.

Ghrelin

A recently discovered peptide hormone secreted by cells in the lining of the stomach. Ghrelin is important in appetite regulation and maintaining the body's energy balance.
Mentioned in: Obesity
References in periodicals archive ?
Research by Cummings' group last year showed that in normal-weight volunteers, the more calories in a meal, the more it suppressed ghrelin production.
In the February JCE&M, the London researchers reported that ghrelin concentrations fell with increasing calories only among the normal-weight men and women.
Moreover, daytime concentrations of ghrelin climbed 28 percent during the sleep-deprived cycle.
From his own work, Cummings notes, ghrelin blockers "look pretty promising.
Currently, Bloom is probing dietary maneuvers to suppress ghrelin peaks and to increase the body's natural production of some of the understudy appetite-quenching hormones.
The stomach hormone called oxyntomodulin also reduces ghrelin concentration and appetite in people.
In its search for appetite suppressors, van der Lely's team is focusing strictly on ghrelin, which comes in two forms.