gestational trophoblastic disease

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hy·da·tid·i·form mole

, hydatid mole [MIM*231090]
a vesicular or polycystic mass resulting from the proliferation of the trophoblast, with hydropic degeneration and avascularity of the chorionic villi; the abnormal tissue typically results from expression of paternally derived chromosomes and a loss of maternal chromosomes.

gestational trophoblastic disease

A generic term for a group of pregnancy-related disorders that arise from the trophoblast and clinically range from banal (e.g., hydatidiform mole) to aggressively malignant (e.g., choriocarcinoma).

Gestational trophoblastic disease
Hydatidiform mole
• Complete mole
• Partial mole
• Invasive mole
Placental site trophoblastic tumour
Epithelioid trophoblastic tumour
Choriocarcinoma

gestational trophoblastic disease

Gynecology A general term for the proliferative processes arising in trophoblastic tissue in ♀ of child-bearing age Types Gestational trophoblastic tumor/neoplasia, molar pregnancy, choriocarcinoma. See Choriocarcinoma, Mole, Trophoblastic tumor.

Gestational trophoblastic disease

A rare, aggressive, malignant, often metastatic (spreading to other organs) cancer in women of childbearing age in which cancer cells grow in the tissues that are formed in the uterus after conception
References in periodicals archive ?
Immunohistochemistry and other ancillary techniques in the diagnosis of gestational trophoblastic diseases.
Schink will oversee the national Gynecologic Oncology Program at CTCA, serving patients in the treatment of cervical, ovarian, uterine, and vaginal and vulvar cancers and gestational trophoblastic diseases.
Gestational trophoblastic diseases are a group of disorders composed of benign lesions like complete mole, partial mole, invasive mole, exaggerated placental site reaction, placental site nodule and malignant lesions like choriocarcinoma, placental site trophoblastic tumour, epithelioid trophoblastic tumour.
Therefore early and rapid diagnosis of gestational trophoblastic diseases in this region is strongly recommended.
Gestational trophoblastic diseases are a spectrum of related disorders which consist of benign trophoblastic lesions, premalignant hydatidiform moles, and neopla-stic diseases.
Epidemiology and aetiology of gestational trophoblastic diseases.
The Gestational trophoblastic diseases (GTD) are a group of pregnancy related disorders arising from abnormal placental trophoblastic cells.
Current understandings of the molecular genetics of gestational trophoblastic diseases.
hCG is synthesized and secreted by trophoblastic tissue of the placenta in pregnancy, gestational trophoblastic diseases, and certain other pathological conditions (2-5).
In the present study, immunohistochemical analyses were performed to examine the expression patterns of ADAMTS1, -4, -5, and -14 in specific human placenta cell types during gestation, in early hydatidiform moles, and in gestational trophoblastic diseases that are characterized by increased trophoblastic invasion placental site trophoblastic tumors (PSTTs), invasive hydatidiform moles, and choriocarcinomas.
Gestational trophoblastic diseases, 2: hyperglycosylated hCG as a reliable marker of active neoplasia.