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germline

   Also found in: Dictionary/thesaurus, Encyclopedia, Wikipedia 0.01 sec.
germline [jerm´līn]
the sequence of cells in the line of direct descent from zygote to gametes, as opposed to somatic cells (all other body cells). Mutations in germline cells are transmitted to offspring; those in somatic cells are not.


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This type of therapy actually involves replacing genes in germline, which will be translated to the next generation," said Mitalipov.
The researchers were surprised to notice a difference between the genome structure in the germline - the cells that become eggs and the sperm that fertilize them - and the genome structure in the resulting embryonic cells.
In the technique developed at Newcastle, stem cells with XY chromosomes (male) were developed into germline stem cells which were then prompted to complete meiosis - cell division with halving of the chromosome set.
 
 
 
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