germinal center

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center

 [sen´ter]
1. a point from which a process starts, especially a plexus or ganglion giving off nerves that control a function.
3. an agency or other site where services are offered to the public.
accelerating center the vasomotor center in the brainstem involved in acceleration of heart action.
apneustic center a nerve center in the brainstem controlling normal respiration.
cardioinhibitory center a vasomotor center in the medulla oblongata that exerts an inhibitory influence on the heart.
cardiovascular control c's vasomotor centers.
community mental health center (CMHC) a mental health facility or group of affiliated agencies that provide services to a designated catchment area.
coughing center a nerve center in the medulla oblongata, situated above the respiratory center, which controls the act of coughing.
deglutition center a nerve center in the medulla oblongata that controls swallowing.
detente center a residential care center of the kinlein type, using the esca theory of moving as the basis for the staff's actions to maintain the independence of residents who are experiencing lessened physical or mental capacity.
C's for Disease Control and Prevention (CDC) an agency of the United States Department of Health and Human Services whose headquarters is in Atlanta, Georgia. It is concerned with all phases of control of communicable, vector-borne, and occupational diseases and with the prevention of disease, injury, and disability. Its responsibilities include epidemiology, surveillance, detection, laboratory science, ecological investigations, training, disease control methods, chronic disease prevention, health promotion, and injury prevention and control. Its major tasks include the licensing of qualified clinical laboratories for interstate commerce, maintenance of laboratories as reference centers for microorganisms and infectious diseases, and operation of extensive research programs in the prevention, detection and control of disease. The CDC's name has changed several times to reflect its expanding role; it has been called the Communicable Disease Center (1946), the Center for Disease Control (1970), and the Centers for Disease Control (1980). The latest name change, enacted by Congress in 1992, reflects the expansion of the scope of the CDC's mission to include health promotion and education. Because of the widespread recognition of the acronym CDC, that acronym continues to be used by the agency. The mailing address of the CDC is Centers for Disease Control and Prevention, 1600 Clifton Rd. NE, Atlanta, GA 30333, and the website is http://www.cdc.gov.
ejaculation center a reflex center in the lumbar spinal cord that regulates ejaculation of semen during sexual stimulation.
erection center a reflex center in the sacral spinal cord that regulates erection of the penis or clitoris. Called also genital center.
feeding center a group of cells in the lateral hypothalamus that when stimulated cause a sensation of hunger; called also hunger center.
genital center erection center.
germinal center the area in the center of a lymph node containing aggregations of actively proliferating lymphocytes.
health center
1. a community health organization providing ambulatory health care and referrals to appropriate service agencies, and coordinating the efforts of all health agencies.
2. an educational complex consisting of a medical college, nursing college, and various allied health professional schools.
heat-regulating c's thermoregulatory centers.
hunger center feeding center.
medullary respiratory center the nerve center in the medulla oblongata that coordinates respiratory movements.
micturition c's a nerve center controlling the bladder and inhibiting the tension of the vesical sphincter, situated in the lumbar enlargement.
nerve center a collection of nerve cells in the central nervous system that are associated together in the performance of some particular function, such as a primary area or an association area.
nursing center a site where public health or primary care services, including patient education, assessment, and screening and preventive services are provided and managed by registered nurses.
center of ossification any point in bones at which ossification begins.
pneumotaxic center a nerve center in the upper pons that rhythmically inhibits inhalation.
poison center (poison control center) see poison control center.
rectovesical center a reflex center in the spinal cord that regulates the rectum and bladder.
reflex center any nerve center at which afferent sensory impressions are converted into efferent motor impulses.
respiratory c's a series of nerve centers (the apneustic, pneumotaxic, and medullary respiratory centers) in the medulla and pons that coordinate respiratory movements.
satiety center a group of cells in the ventromedial hypothalamus that when stimulated suppress the desire for food.
senior center a program supported by Title XX funding, providing recreational activities and lunch for a small fee for older adults in need of socialization. Health assessments and education may also be provided.
sudorific center
1. a nerve center in the anterior hypothalamus controlling sweating.
2. any of several nerve centers in the medulla oblongata or spinal cord that exercise parasympathetic control over sweating. Called also sweat center.
swallowing center deglutition center.
sweat center sudorific center.
thermoregulatory c's nerve centers in the hypothalamus that regulate the conservation and dissipation of heat.
thirst center a group of cells in the lateral hypothalamus that when stimulated cause a sensation of thirst.
trauma center an institution officially designated as a site to which catastrophically injured patients can be brought quickly to receive specialized care. Trauma centers are classified as Level I, II, or III according to criteria developed by the Committee on Trauma of the American College of Surgeons, with Level I facilities having the equipment and personnel necessary to care for the most seriously injured patients.
vasoconstrictor center a nerve center in the medulla oblongata and lower pons that controls contraction of the blood vessels.
vasodilator center a nerve center in the medulla oblongata that causes dilation of blood vessels by repressing the activity of the vasoconstrictor center.
vasomotor c's nerve centers in the medulla oblongata and the lower pons that regulate the caliber of the blood vessels and increase or decrease the heart rate and contractility. See also vasoconstrictor c. and vasodilator c. Called also cardiovascular control c's.
vomiting center a center in the lower central region of the medulla oblongata; its stimulation causes vomiting.
word center, auditory Wernicke's area.

germinal center

area in a lymph node or other tissue such as liver (in infection with hepatitis C virus) and synovium (in patients with rheumatoid arthritis) in which there is a rapid clonal expansion of antigen-specific B cells.

germinal center

Etymology: L, germen, sprout; Gk, kentron, center
an antigen-localizing follicle of lymphoid tissue, occupying the center of the lymphatic nodules of the spleen, tonsils, and lymph nodes. It reacts to antigens, enlarging and becoming filled with lymphoblasts and macrophages at the center of a ring of small lymphocytes.

center

a point from which a process starts, especially a plexus or ganglion giving off nerves that control a function.

accelerating center
one in the brainstem involved in acceleration of heart action.
appetite center
located in the hypothalamus; controls appetite.
auditory center
the center for hearing, in the more anterior of the transverse temporal gyri.
cardioinhibitory center
one in the medulla oblongata that exerts an inhibitory influence on the heart.
deglutition center
a nerve center in the medulla oblongata that controls swallowing.
diaphragmatic center
see diaphragmatic tendon.
emetic center
located in the reticular formation of the brainstem, this center controls vomiting.
eructation center
controls eructation in ruminants; located in the medulla oblongata.
expiratory center
one of the four respiratory centers (see below).
germinal center
the area in the center of a lymph node containing aggregations of actively proliferating lymphocytes.
gustatory center
the cerebral center supposed to control taste.
inspiratory respiratory center
one of the four respiratory centers.
lymph node germinal center
centers in lymph nodes where lymphocytes are produced.
medullary respiratory center
the center in the medulla oblongata that coordinates respiratory movements.
motor center
any center that originates, controls, inhibits or maintains motor impulses.
nerve center
a collection of nerve cells in the central nervous system that are associated together in the performance of some particular function.
center of ossification
see ossification center.
perineal center
see perineal body.
reflex center
any nerve center at which afferent sensory information is converted into efferent motor impulses.
respiratory c's
a series of the centers (the apneustic, pneumotaxic and medullary respiratory centers) in the medulla and pons that coordinate respiratory movements.
center-surround retinal organization
the arrangement of cells in the receptive field of the retina; the sensitivity of a certain spot in the retina is affected by what is occurring in adjacent areas.
swallowing center
deglutition center.
thermoregulatory c's
hypothalamic centers regulating the conservation and dissipation of heat.
vasomotor center
a combination of two centers in the reticular formation of the brainstem; includes a pressor and a depressor center.
vomiting center
see emetic center (above).
References in periodicals archive ?
The lymphoid depletion, however, recovered approximately 2 weeks postinfection, but the loss of germinal centers persisted during the latent phase of infection in both lines.
There is an infiltrate of chronic inflammatory cells, often forming germinal centers (figure 1).
4,8) The histologic patterns seen in these lymph node biopsy specimens include follicular hyperplasia, interfollicular/immunoblastic hyperplasia, plasma cell-type Castleman disease-like, progressive transformation of germinal centers, and nodal inflammatory pseudotumor-like.
In the IL-21 receptor deficient mice, germinal centers form but are not sustained.
Other papers consider the growth of gliomas, the concept of the gene and the mechanisms of gene expression, a differential geometric approach to the influence of the drying effect on the dynamics of pods of Leguminosae, the comparison of agent-based models with the approach of differential equations on the study of selection mechanisms in germinal centers, and the synchronization phenomenon for protocell systems driven by linear kinetic equations.
These results were not specific enough to be considered diagnostic; however, germinal centers are present in 80% of borrelial lymphocytoma cases (12).
The researchers then engineered mice to aberrantly express the TCL1 gene and those mice developed B-NHLs at a very high rate, within the germinal centers of lymphoid tissues, such as lymph nodes and the spleen, where B cells normally develop.
The researchers also discovered that nonprogressers trapped less HIV in their lymph node germinal centers, regions of cell proliferation, than the 18 progressers.
The CD4 T cells serving as reservoir for HIV infection and as primary site for HIV replication and production are not present in the blood and are exclusively found in the lymphoid tissues in a region called germinal centers.
The germinal centers often have a starry-sky appearance because of the relatively numerous tingible-body macrophages and mitotic figures present.
Germinal centers are usually lost, although germinal center colonization is sometimes seen.
Germinal centers are the site of antibody production within the periphery of lymph nodes and are populated mostly by B-cells.