germ-free animal

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germ-free animal

a laboratory animal raised under sterile conditions, free of exposure to microorganisms. The diet is controlled, preventing exposure to microorganisms that may be in food. The germ-free animals have lymphoid tissue that is not fully developed and may have a deficiency of serum immunoglobulin.
References in periodicals archive ?
Germfree animals not only appear less efficient at harvesting calories, he explains, but also "are prone to certain vitamin deficiencies" because gut microbes synthesize certain nutrients, such as vitamins [B.
On the other hand, germfree animals upon conventionalization show an increase in vasculature, as angiogenesis is restarted (46).
Scientists have generally used such germfree animals to study how particular pathogens cause diseases.