germline

(redirected from Germ-line)
Also found in: Dictionary, Encyclopedia.

germline

 [jerm´līn]
the sequence of cells in the line of direct descent from zygote to gametes, as opposed to somatic cells (all other body cells). Mutations in germline cells are transmitted to offspring; those in somatic cells are not.

germline

or

germ line

(jûrm′līn′)
n.
1. The gamete-producing cells in a sexually reproducing organism, by means of which genetic material is passed on to subsequent generations.
2. The collection or sequence of such cells in an individual and all its descendants.

germ line

, germline
The cells from which the gametes (the ova and sperm) originate.
References in periodicals archive ?
Germ-line transmission of a disrupted beta 2-microglobulin gene produced by homologous recombination in embryonic stem cells.
Solnica-Kretzel L, Schier A, Driever W (1994) Efficient recovery of ENU-induced mutations from the zebrafish germ-line.
However, it is important to realize that a treatment similar to germ-line modification has been completed on humans.
Their research showed that primordial follicles are highly stable, and that germ-line stem cell activity cannot be detected, even in response to the death of half the existing follicles.
When pluripotent germ-line cells commit to become one of the life-functioning cell types of the body, we say they have differentiated into somatic cells.
Isolation of male germ-line stem cells; influence of GDNF.
Nine percent of women who are given a diagnosis of endometrial cancer before 50 years of age have a germ-line Lynch syndrome-associated mutation, which demonstrates that heredity is an important aspect of endometrial cancer and should be considered at all times.
James Keenan, professor of ethics at Boston College, applies his well-honed theory of virtue ethics to issues such as enhancement and germ-line gene therapy.
By comparison, rare germ-line variants of CDKN2A account for ~25% of familial melanoma cases (15) but only a tiny proportion of melanoma in the general population (16).
In a retrospective study of patients who had germ-line mutations associated with hereditary nonpolyposis colorectal cancer (Lynch syndrome), significantly fewer endometrial cancers occurred in women who had a prophylactic hysterectomy (0 of 61) than in those who did not (69 of 210).
In a retrospective study of a cohort of patients who had germ-line mutations associated with hereditary nonpolyposis colorectal cancer (Lynch syndrome), significantly fewer endometrial cancers occurred in women who had a prophylactic hysterectomy (0 of 61) than in those who did not (69 of 210).
All cells of the early human embryo are totipotent until shortly after the blastocyst stage, including the cells of the inner cell mass and even the primitive germ-line cells.