promoter

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pro·mo·ter

(prō-mō'tĕr),
1. In chemistry, a substance that increases the activity of a catalyst.
2. In molecular biology, a DNA sequence at which RNA polymerase binds and initiates transcription.

promoter

/pro·mo·ter/ (pro-mo´ter)
1. a segment of DNA usually occurring upstream from a gene coding region and acting as a controlling element in the expression of that gene.
2. a substance in a catalyst that increases its rate of activity.
3. a type of epigenetic carcinogen that promotes neoplastic growth only after initiation by another substance.

promoter

(prə-mō′tər)
n.
1. One that promotes, especially an active supporter or advocate.
2. A financial and publicity organizer, as of a boxing match or an artistic performance.
3. Genetics The region of an operon that acts as the initial binding site for RNA polymerase.

promoter

[-mō′tər]
Etymology: L, promovere, to move forward
1 a DNA sequence that initiates transcription of the genetic code.
2 a cocarcinogen that encourages cells altered by initiators to reproduce more rapidly than normal, increasing the probability of malignant transformation. Examples include chlorophenothane (DDT), phenobarbital, saccharin, sunlight, and some chemicals in cigarette smoke. The effects of promoters are sometimes reversible.

pro·mo·ter

(prŏ-mō'tĕr)
1. chemistry A substance that increases the activity of a catalyst.
2. molecular biology A DNA sequence at which RNA polymerase binds and initiates transcription.

promoter

In genetics, a nucleotide sequence at the start of a gene to which RNA polymerase must bind before the process of transcription can start. The promoter is located UPSTREAM of the gene it regulates.

promoter

a cis- acting (see CIS -ACTIVE) NUCLEOTIDE sequence on a DNA molecule which promotes the initiation of TRANSCRIPTION by allowing the assembly of proteins, including RNA POLYMERASE (or its equivalent), in transcriptional complexes. see OPERON MODEL. The promoter generally lies UPSTREAM of the transcription start site.

promoter

a specific DNA sequence to which RNA polymerase binds and signals where RNA synthesis (transcription) should begin.

internal promoter
a class of enhancers which are gene-specific sequences that increase transcription.
promoter region
the non-coding nucleotide sequence at the transcription start region that is characterized by the presence of a number of conserved or consequence sequences.

Patient discussion about promoter

Q. I am interested in social service. So what can I do to promote a healthy pregnancy?

A. Hi friend, once you're pregnant, a regular checkup is the key. Your health professional might want to monitor your baby's growth and watch for problems that can only be detected by checking your blood pressure, urine, and blood regularly. Anything you do that harms your body harms your fetus. Take special care: To avoid: tobacco smoking, alcohol, drugs, chemicals, radiation (as from X-rays), and sources of infection. Keep your body temperature from getting too high [over 100.4° (38°)] by treating any fevers with acetaminophen (such as Tylenol) and avoiding exercise or activity that overheats you. Also avoid high-temperature hot tubs and saunas. Take extra-good care of yourself while you're pregnant. Everything healthy you do for your body benefits your growing fetus. Rest when you need it, eat well, and exercise regularly.

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References in periodicals archive ?
The results of the present study identify a different susceptibility to the apo C-111-lowering effects of a diet rich in n-3 PUFAs of fish origin in individuals carrying a polymorphic "insulin-resistant" variant on the APOC3 gene promoter.
As in the CENTRIC trial, the CORE trial will rely on MDxHealth's MGMT gene promoter methylation assay for the stratification of patients.
The -174 G/C polymorphism of the interleukin-6 gene promoter is associated with peripheral artery occlusive disease.
In conclusion, the HO-1 gene promoter polymorphism and DM are independent prognostic risk factors for patients who develop a restenosis after PCI with stmt implantation, and the effect of the HO-1 class L allele as a risk factor for restenosis is significantly attenuated in smokers.
CENTRIC is a randomized Phase III clinical trial assessing the efficacy and safety of the investigational integrin inhibitor, cilengitide, in combination with standard treatment (radiotherapy plus temozolomide, followed by temozolomide maintenance therapy) versus standard treatment alone in newly diagnosed glioblastoma patients with a methylated methylguanine-DNA methyltransferase (MGMT) gene promoter in the tumor tissue.
Prolactin and glucocorticoid hormones synergistically induce expression of transfected rat beta-casein gene promoter constructs in a mammary epithelial cell line.
Substances aren't the only sources of epigenetic changes The licking, grooming, and nursing methods that mother rats use with their pups can affect the long-term behavior of their offspring and those results can be tied to changes in DNA methylation and histone acetylation at a glucocorticoid receptor gene promoter in the pup's hippocampus.
In the present study, we observed that ZnO exposure increased the binding of p65 to the IL-8 gene promoter and also increased the phosphorylation of p65 at Ser276 and Ser536 in BEAS-2B cells.
Association between polymorphism of tumour necrosis factor a-308 gene promoter and asthma: a meta-analysis.
Kerr, then at the Agriculture Department, attached the genetic sequence for human growth hormone to the uroplakin gene promoter, which controls where and when the gene switches on.
In a previous study, the PPARG2 gene promoter in 3T3-L1 preadipocytes was hypermethylated, but was also progressively demethylated upon the induction of differentiation, which was accompanied by an increase in mRNA expression (Fujiki et al.
Differential requirement for DNA methyltransferase 1 in maintaining human cancer cell gene promoter hypermethylation.