knockdown

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Related to Gene knockdown: Gene knockout
The alteration of a gene’s function so that it is conditionally expressed, a manoeuvre required when complete gene knockout would be lethal to the organism

knockdown

A modification of a gene that limits its expression to specified conditions or circumstances.

knockdown

a measure of biocide effect that is used when it is difficult to assess actual mortality. The measure is used particularly in biocide tests on insects, and has been shown to produce similar results to actual mortality scores. Knockdown is often measured as the inability to respond to a stimulus such as light or touch. see KNOCKDOWN LINE.
References in periodicals archive ?
This is the first report for validation of plasmid and siRNA transfection and CYP19 gene knockdown in buffalo (Bubalus bubalis) granulosa cells.
The subcutaneous DPCs have shown striking levels of target gene knockdown, which we are pleased to have the opportunity to discuss at the OTS meeting," said Bruce D.
They used a human siRNA library to perform a whole kinome screen, targeting 779 kinases and 80 cell cycle genes to analyze cell proliferation in real time, by monitoring the dynamics of the cellular responses after high-throughput gene knockdown.
The poster demonstrates that SurModics' Eureka(TM) DUET polymer platform can be used for sustained release of cationic lipid/siRNA complexes which retain high levels of gene knockdown activity.
This visionary platform has enormous potential to combine into one nanoparticle all possible RNA functionalities including receptor antagonism/activation, cell targeting/delivery and gene knockdown through mechanisms like RNA interference.
Some examples of specific topics include derivation and manipulation of murine embryonic stem cells, efficient gene knockdowns in human embryonic stem cells using lentiviral-based RNAi, ex vivo megakaryocyte expansion and platelet production from human cord blood stem cells, isolation and manipulation of mammalian neural stem cells in vitro, regeneration of skin and cornea by tissue engineering, template DNA- strand co-segregation and asymmetric cell division in skeletal muscle stem cells, derivation of contractile smooth muscle cells from embryonic stem cells, and reprogramming of liver to pancreas.