copy number

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copy number

  1. the number of copies of a particular PLASMID per CHROMOSOME present in a CELL.
  2. the number of copies of a GENE in the GENOME of an ORGANISM.

copy number

the number of plasmid or other DNA molecules in a cell.
References in periodicals archive ?
PCR detected a decrease in MYC gene copy number in six tumors, one of which also showed loss of genetic material at 8g24 by CGH.
Thus, a doubling of the SMN2 gene copy number dramatically alters disease course and suggests that a therapy which increases the level of SMN protein may provide a significant clinical benefit.
As expected, the F9 gene copy number was correctly determined in control groups because it was two times higher in females than in males, demonstrating the reliability of the method to detect patients heterozygous for deletions because unaffected male samples mimic carriers for the gene deletion.
The system detects slight differences in gene copy number (i.
CP values are linearly proportional to gene copy number in an inverse logarithmic relationship (14,15), and this correlation is central to algorithms for determining gene quantity (16, 17).
Unfortunately, in real-time PCR methods (kinetic PCR), template/primer combinations may be very sensitive to subtle temperature inhomogeneities that may exist in real-time PCR instruments, reflecting the specific melting behavior of the amplicon and its flanking genomic sequences, which can lead to unpredictable variation of the results by a factor of two or three (16) and make such assays unsuitable for the precise and reliable quantitative analysis of gene copy number.
Recent clinical studies show an association between high EGFR gene copy number and favorable clinical benefit for advanced NSCLC patients who are treated with new targeted therapies such as Iressa(R) (gefitinib) or Tarceva(R) (erlotinib).
The current scope of microarray applications includes sequencing by hybridization, resequencing, mutation detection, assessment of gene copy number, comparative genome hybridization, drug discovery, expression analysis, and immunoassay (protein microarrays).
ERBB-2 (HER2/neu) gene copy number, p185HER-2 over-expression, and intratumor heterogeneity in human breast cancer.
Indeed, determination of the gene copy number after hybridization to CFTR cDNA is hazardous because the intensity of hybridization signals may vary with exon length.
Additional applications based on Quantitative Gene Analysis that are being considered or are under development at SEQUENOM include strain-specific Viral Load Determination, Gene Copy Number determination, Loss of Heterozygosity in cancer and Vaccine Quality Control.