gemcitabine

gemcitabine /gem·cit·a·bine/ (jem-sit´ah-bēn) an antineoplastic agent used as the hydrochloride salt in the treatment of pancreatic adenocarcinoma and non.

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gemcitabine,

a miscellaneous antineoplastic.

indications It is used to treat adenocarcinoma of the pancreas (nonresectable Stages II and III or metastatic Stage IV) and non-small-cell lung cancer (Stages IIIA or B and IV). It is also used in combination with cisplatin to treat inoperable, advanced, or metastatic non-small-cell lung cancer.

contraindications Known hypersensitity and pregnancy prohibit its use.

adverse effects Life-threatening effects are leukopenia, anemia, neutropenia, thrombocytopenia, and hemorrhage. Other adverse effects include diarrhea, nausea, vomiting, anorexia, constipation, stomatitis, irritation at the site of administration, rash, alopecia, dyspnea, fever, and infection.

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gemcitabine

Gemzar^™ Oncology An IV antimetabolic antineoplastic used with cisplatin for inoperable non-small cell lung CA, and as a single agent for inoperable pancreas CA Side effects ↓ WBCs and platelets; ↑ liver enzymes; 10% discontinued medication due to flu-like Sx, N&V, rash. See Cisplatin. Cf 5-FU.