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Pepsin B; a metalloproteinase that hydrolyzes gelatin and a number of types of collagen. See: pepsin.



MMP-2; MMP-9

Metalloproteinases that cleave gelatin, or nondenatured collagen. Two forms of gelatinase, A and B, have been identified. Gelatinase A (MMP-2) has a molecular weight of about 72,000, and gelatinase B (MMP-9) has a molecular weight of about 92,000. Both are involved in cancer angiogenesis and metastasis and are blocked by a variety of naturally occurring and synthetic inhibitors.
References in periodicals archive ?
Gelatinases, endonuclease and Vascular Endothelial Growth Factor during development and regression of swine luteal tissue.
In the present study, we compared the selectivity of SalA on collagenases and gelatinases which are two kinds of MMPs that play important roles in aortic remodeling.
Selected Efs and Efm isolates were evaluatedfor the expression of three virulencefactors: gelatinase, cytolysin (hemolysin), and bacteriocin.
The Notre Dame group has been investigating variants of a compound called "SB-3CT," which shows promise as a selective and potent gelatinase inhibitor.
Development of intimal hyperplasia and early events of atherosclerosis are usually associated with the expression and activities of gelatinases (MMP-2 and MMP-9) (7,9,25).
Expression of matrix metalloproteinase 9 (96-kd gelatinase B) in human rheumatoid arthritis.
Trabodenoson is a first-in-class, highly selective A1 subtype adenosine mimetic for glaucoma and ocular hypertension that binds to epithelial cells in the trabecular meshwork, up-regulating gelatinases that clean out and remodel the meshwork, increasing outflow and restoring a healthier IOP.
Ventilator-induced lung injury upregulates and activates gelatinases and EMMPRIN: attenuation by the synthetic matrix metalloproteinase inhibitor, Prinomastat (AG3340).
Monoxide exposure caused a significant increase in the relative activity of vascular gelatinases (Figure 6B-F).
Our data demonstrate that in blood the measured concentrations of not only the gelatinases but also of other MMPs are strongly influenced by the sampling procedure.
Matrix metalloproteinase degradation of elastin, type IV collagen and proteoglycan: a quantitative comparison of the activities of 95 kDa and 72 kDa gelatinases, stromelysins-1 and -2 and punctuated metalloproteinase (PUMP).