gelatinase

(redirected from Gelatinase b)
Also found in: Encyclopedia.

gel·a·tin·ase

(jĕ-lat'i-nās),
Pepsin B; a metalloproteinase that hydrolyzes gelatin and a number of types of collagen. See: pepsin.

gelatinase

(jĕl′ă-tĭn-ās),

MMP-2; MMP-9

Metalloproteinases that cleave gelatin, or nondenatured collagen. Two forms of gelatinase, A and B, have been identified. Gelatinase A (MMP-2) has a molecular weight of about 72,000, and gelatinase B (MMP-9) has a molecular weight of about 92,000. Both are involved in cancer angiogenesis and metastasis and are blocked by a variety of naturally occurring and synthetic inhibitors.
References in periodicals archive ?
A gelatinase B (MMP-9) e a primeira MMP a ser sintetizada e secretada por celulas epiteliais basais apos lesao corneal, sendo detectado um rapido aumento na sua expressao com apenas um dia apos lesao e declinio apos poucas semanas, enquanto a gelatinase A (MMP-2), a estromalisina e a colagenase sao apresentadas normalmente no estroma corneal e aumentam gradualmente por varios meses, demonstrando o envolvimento na remodelacao tecidual (3).
For example, in multiple sclerosis (MS) a metalloenzyme known as gelatinase B is believed to play a role in causing damage to the myelin sheath that protects neurons in the central nervous system.