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Gee-Thaysen disease[ge´ ti´sen]
the adult form of celiac disease.
coeliac diseaseA malabsorptive syndrome caused by hypersensitivity of intestinal mucosa to alpha-gliadin, a gluten extract composed of glutamine and proline-rich proteins that is found in wheat, barley, rye, and oats.
Diarrhoea, copious fatty stools, abdominal distension, weight loss, haemorrhage, osteopenia, muscle atrophy, peripheral neuropathy, CNS and spinal cord demyelination (sensory loss, ataxia), amenorrhoea, infertility, oedema, petechiae, dermatitis herpetiformis (especially if HLA B27), alopecia areata. Occult bleeding occurs in half of patients.
Transaminases (ALT, AST) are increased in ± 40% of patients with CD, which usually normalises with a gluten-free diet; iron deficiency, anaemia due to occult bleeding.
Duodenal biopsy; anti-gliadin and anti-endomysial antibodies.
Eliminate gliadin from diet.
Without treatment, 10–15% develop lymphoma (e.g., immunoblastic lymphoma; less commonly, T cell lymphoma), a risk that increases with disease duration. CD predisposes to gastrointestinal lymphoma and carcinoma of the oral cavity and oesophagus; the otherwise rare small intestinal adenocarcinoma is 80-fold more common in CD.
[Gee, Samuel J.; Thorwald E. H. Thaysen, Danish physician, 1883–1936]Celiac disease.
Gee,Samuel J., English pediatrician and physician, 1839-1911.
Gee disease - malabsorption syndrome in infants.Synonym(s): Gee-Herter disease; Gee-Thaysen disease; Heubner-Herter disease
Gee-Herter disease - Synonym(s): Gee disease
Gee-Thaysen disease - Synonym(s): Gee disease
Thaysen,Thornwald Einar Hess, Danish physician, 1883-1936.
Gee-Thaysen disease - see under Gee
Thaysen syndrome - Synonym(s): Maclennan syndrome