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gatifloxacin |
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gatifloxacin /gat·i·flox·a·cin/ (gat?i-flok´sah-sin) a fluoroquinoloneantibacterial effective against many gram-positive and gram-negative bacteria. gatifloxacin a fluoroquinolone antibiotic with activity against anaerobic bacteria. gatifloxacin Zymar Pharmacologic class: Fluoroquinolone Therapeutic class: Anti-infective Pregnancy risk category C ActionInhibits bacterial DNA gyrase (enzyme involved in bacterial DNA replication, transcription, and repair) in susceptible gram-negative and gram-positive aerobic and anaerobic bacteria AvailabilityOphthalmic solution: 0.3% (5 ml in 8-ml bottle with dropper) ⊘Indications and dosages ➣ Bacterial conjunctivitis caused by susceptible strains of Corynebacterium propinquum, Haemophilus influenzae, Staphylococcus epidermidis, Staphylococcus aureus, Streptococcus mitis, and Streptococcus pneumoniae Adults and children ages 1 and older: One drop every 2 hours in affected eye(s) while awake, up to eight times daily on days 1 and 2; then one drop up to four times daily while awake on days 3 to 7 Contraindications• Hypersensitivity to drug, its components, or other quinolones PrecautionsUse cautiously in: Administration• Don't inject subconjunctivally.
Adverse reactionsCNS: headache EENT: reduced visual acuity, conjunctival irritation or hemorrhage, increased lacrimation, keratitis, papillary conjunctivitis, chemosis, dry eye, eye discharge, eye irritation or redness, eye pain, eyelid edema Other: abnormal taste, superinfection (with prolonged use), allergic reaction InteractionsNone Patient monitoring☞ Stop drug and immediately report signs or symptoms of allergic reaction, including rash, itching, swelling, dizziness, and trouble breathing. Patient teaching• Teach patient how to use eyedrops. Caution him not to let dropper tip touch eye, finger, or other surfaces. |
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? Mentioned in | ? References in periodicals archive | |
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gatifloxacin, amoxicillin, cloxacillin, and amoxicillin/clavulanic acid) and nasal decongestants (e. The isolate from blood was resistant to levofloxacin (MIC 8 mg/L) and ciprofloxacin (MIC 8 mg/L), yet susceptible to gatifloxacin (MIC 1 mg/L) and ceftriaxone (MIC 0. TSE: 4560), Tokyo, have entered into a license agreement for the development and commercialization of gatifloxacin for the treatment of ocular infections. |
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