ganglioside

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Related to Gangliosides: sialic acid, Cerebrosides, Glycolipids, gangliosidosis, Glycosphingolipids

ganglioside

 [gang´gle-o-sīd]
a class of galactose-containing cerebrosides found in central nervous system tissues; they are glycolipids of the basic composition ceramide-glucose-galactose-N-acetyl neuraminic acid. The form GM1 accumulates in tissues in generalized gangliosidosis, the form GM2 in Tay-Sachs disease.

gan·gli·o·side

(gang'glē-ō-sīd),
A glycosphingolipid chemically similar to cerebrosides but containing one or more sialic (N-acetylneuraminic or N-glycolylneuraminic) acid residues; found principally in nerve tissue, spleen, and thymus; ganglioside GM1 accumulates in generalized gangliosidosis; GM2 accumulates in Tay-Sachs disease.

ganglioside

/gan·glio·side/ (gang´gle-o-sīd) any of a group of glycosphingolipids found in the central nervous system tissues and having the basic composition ceramide-glucose-galactose-N -acetylneuraminic acid. The form GM1 accumulates in tissues in GM1 gangliosidoses and the form GM2 in GM2 gangliosidoses.

ganglioside

(găng′glē-ə-sīd′)
n.
Any of a group of galactose-containing cerebrosides found in the surface membranes of nerve cells.

ganglioside

[gang′glē·əsīd′]
a glycosphingolipid found in the brain and other nervous system tissues. Gangliosides are members of a group of galactose-containing cerebrosides with a basic composition of ceramide-glucose-galactose-N-acetyl neuraminic acid. Accumulation of gangliosides caused by an inborn error of metabolism results in gangliosidosis or Tay-Sachs disease.

gan·gli·o·side

(gang'glē-ō-sīd)
Glycosphingolipid chemically similar to cerebrosides but containing one or more sialic acid residues; found principally in nerve tissue, spleen, and thymus; GM1 accumulates in generalized gangliosidosis; GM2 accumulates in Tay-Sachs disease.

ganglioside

A compound of fat and carbohydrate (glycolipid) that is an important component in cell membranes.

Ganglioside

A fatty (lipid) substance found within the brain and nerve cells.
Mentioned in: Tay-Sachs Disease

ganglioside

a class of galactose-containing cerebrosides found in central nervous system tissues; they are glycolipids of the basic composition ceramide-glucose-galactose-N-acetyl neuraminic acid. The form GM1 accumulates in tissues in generalized gangliosidosis as observed in Friesian cattle, dogs and cats. The form GM2 accumulates in a similar disease of Yorkshire pigs, dogs and cats.
References in periodicals archive ?
Human IgM monoclonal antibodies (mAb) to ganglioside GM3 (L612) (13), ganglioside GM2 (L55) (14), and ganglioside GD2 (L72) (15) were developed by R.
Reduction of gangliosides, phospholipids and cholesterol content in cerebral cortex of rats caused by chronic hypermethioninemia.
Secondly, as discussed above, both CT and LT also bind with high affinity via their B-subunits to GM1 ganglioside receptors, which are present on most mammalian cells including not only epithelial cells, such as the "M cells" covering the Peyer's patches, but also all known antigen-presenting cells (APCs); this facilitates the uptake and presentation of the toxins to the gut mucosal immune system.
Gangliosides expresses by renal cell carcinoma cell line SK-RC-45 are involved in tumour-induced apoptosis of T cells.
2] gangliosides results in glial cell proliferation, or reactive gliosis.
Characterization and biological activity of gangliosides in buffalo milk.
What you should know is that gangliosides are made by every cell.
Gangliosides are a family of sialic acid containing glycolipids that are present in most mammalian cells and highly concentrated in neuronal membranes.
They focused on antibodies against gangliosides -- molecular markers found on cancer cells but not on normal cells.
Under the amended agreement, Progenics has the right to negotiate with Neose for the supply of two gangliosides for use as the active pharmaceutical ingredients in the cancer vaccines.
Although the structural analysis was performed with simple gangliosides, we analyzed the major source of the CA19-9 antigen in patients' sera and to our surprise discovered that it originated mainly from mucins secreted from these adenocarcinomas into the bloodstream (48).
Gliadin has been shown to cross-react with multiple organs and tissues, including cerebral function (reflected in impact on gangliosides and synapsins), and effects on thyroid and on reproductive organs.