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gamma-glutamyl transferase

   Also found in: Wikipedia 0.01 sec.
gamma-glutamyl transferase
Gamma-glutamyl transpeptidase Lab medicine An enzyme that catalyzes the transfer of a γ-glutamyl group from glutathione or γ-glutamyl peptide to another peptide or amino acid; GGT is located on the cell membrane and microsomal fractions and is involved in amino acid transport across cell membranes; GGT is highest in the liver–GGT is the best single screening assay for detecting latent or chronic liver disease–eg, CA; in hepatobiliary diseases, a 10-fold + ↑ in GGT is seen in liver cancer, hepatic metastases, and PBC; a 4-fold + ↑ in GGT is seen in chronic active hepatitis, intrahepatic cholestasis, alcoholic hepatitis, extrahepatic biliary obstruction, and inactive cirrhosis


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