GYS2

GYS2

A gene on chromosome 12p12.2 that encodes liver glycogen synthase, which catalyses the rate-limiting step in glycogen synthesis—the transfer of a glucose residue from uridine diphosphate (UDP) glucose to a terminal branch of a glycogen chain.

Molecular pathology
Defects of GYS2 cause glycogen storage disease type 0.
References in periodicals archive ?
As described in the study abstract, the SiDMAP findings, taken together with data on Roche GSA3 activator RO5289867, "provide evidence that direct pharmacological activation of GYS1 and GYS2 can lead to beneficial effects in whole body substrate metabolism and may be a viable approach for treating T2D and its co-morbidities.