GYS1

GYS1

A gene on chromosome 19q13.3 that encodes glycogen synthase, which adds glucose monomers to growing glycogen chains by forming alpha-1,4-glycoside linkages.

Molecular pathology
Defects of GYS1 cause glycogen storage disease type 0b.
References in periodicals archive ?
cinnamon extract; DMEM, Dulbecco's modified Eagle's medium; GLUT, glucose transporter; GSK3B, glycogen synthase kinase 3 beta; GYS1, glycogen synthase 1; IGF, insulin-like growth factor; IGFR, insulin-like growth factor receptor; INS, insulin; INSR, insulin receptor; IRS, insulin receptor substrate; LEP, leptin; LEPR, leptin receptor; PIK3CB, phosphatidylinositol 3-kinase, catalytic, beta; PIK3R1, phosphatidylinositol 3-kinase, regulatory subunit 1; RPL32, ribosomal protein L32; SHC1, Src homology 2 domain-containing transforming protein 1; SOS1, Son of sevenless 1; TTP, tristetraprolin; ZFP36, zinc finger protein 36.
As described in the study abstract, the SiDMAP findings, taken together with data on Roche GSA3 activator RO5289867, "provide evidence that direct pharmacological activation of GYS1 and GYS2 can lead to beneficial effects in whole body substrate metabolism and may be a viable approach for treating T2D and its co-morbidities.