GNAS

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GNAS

A locus on chromosome 20q13.3 that has a highly complex imprinted expression pattern, giving rise to maternally, paternally and biallelically expressed transcripts derived from four alternative promoters and 5' exons. Some transcripts have a differentially methylated region (DMR) at their 5' exons. This DMR is commonly found in imprinted genes and correlates with transcript expression; one transcript produced from this locus and the antisense transcript are paternally expressed, noncoding RNAs, which may regulate regional imprinting. Alternative splicing of downstream exons results in different forms of the stimulatory G-protein alpha subunit, a key component of the classical signal-transduction pathway linking receptor-ligand interactions to adenylyl cyclase activation and various cellular responses.

Molecular pathology
GNAS mutations have been linked to pseudohypoparathyroidism types 1a and 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone and pituitary tumours.
References in periodicals archive ?
This release of the comprehensive revision of GSP is another step in updating and extending the regional accounts, as outlined in BEA'S strategic plan for improving the accuracy, reliability, and relevance of the national, regional, and international accounts.
Eligibility reviews under the GSP program typically involve a public hearing and the solicitation of views from interested stakeholders.
Director of GSP Fivos Constantinides said that the GSP facilities and the Allegra Sports Center are being constantly upgraded to cover the needs of European federations.
To view product information and a video on Farr GSP collectors, go to www.
However, the European Union GSP reform carried out in early 2014 illustrates that this is no longer so straightforward.
Sahragti added that under the United State's GSP programme, developing countries were allowed to export duty-free a total of 3,400 products if they fulfilled a set of trade criteria.
The GCC member states currently benefit from preferential access to the EU market under the GSP, a system which provides preferential access to some countries in the form of reduced tariffs for goods entering the EU," says a report on EU's official website.
The GSP aims at helping developing countries by making it easier for them to export their products to the EU.
The major highlights of the promotion include; a LIVE PokerCam appearance from GSP himself in the $3000 GSP PokerCam Fight on 09 Sep (players will get the chance to play poker face-to-face with GSP via webcam) and the massive $10,000 GSP GIANT Freeroll on 01 Sep .
The GSP flowrap machines, which are made to the client's specification, can wrap hundreds of items per minute.
ISLAMABAD, June 5 -- Belgium fully supports Pakistan to have European Union's Generalised System of Preferences (GSP) Plus facility, however, Pakistan has to ratify the human rights agreement, which is one of the basic conditions for getting GSP Plus facility, said Ambassador of Belgium, Hans Christian Kint while addressing business community at Islamabad Chambers of Commerce & Industry (ICCI).
The press release said that by means of the GSP trade arrangements, the EU provides preferential access to the EU Market to 176 developing countries, including Yemen, in the form of reduced tariffs for their goods.