GSK3B


Also found in: Acronyms.

GSK3B

A gene on chromosome 3q13.3 that encodes a serine-threonine kinase of the glycogen synthase kinase subfamily, which is involved in glycogen metabolism, proliferation, motility, survival, neuronal development and body pattern formation.
 
Molecular pathology
GSK-3 plays a role in diabetes, cancer and neurologic disease—GSK3B polymorphisms are implicated in Parkinson disease; GSK3B overexpression may play a role in Alzheimer’s disease.
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5] Nonstandard abbreviations: miRNA or miR, microRNA; 3'-UTR, 3'-untranslated region; HIF, hypoxia-inducible factor; AR, androgen receptor; PI3K/Akt, phosphatidylinositol 3-kinase/RAC-alpha serine/threonine-protein kinase; CDK1B, cyclin-dependent kinase inhibitor 1B; GSK3B, glycogen synthase kinase 3 beta; PTEN, phosphatase and tensin homolog; PSA, prostate-specific antigen; VHL, von Hippel-Lindau tumor suppressor; HIF1A, hypoxia inducible factor 1; VEGF, vascular endothelial growth factor; FGFR3, fibroblast growth factor receptor 3.
For example, both CE and insulin decreased the expression of GSK3B, IGF1R, and 1GF2R [Fig.
Irreversibly reduced expression of another gene, GSK3B, in smokers could account for an exaggerated inflammatory response and contribute to the development of lung cancer, said the scientists.
Nine candidates failed the initial criteria, such as assay length or unsuitable CpG site location for primer and probe placement [BCOR, BCL6 co-repressor; CAV1, caveolin 1, caveolae protein, 22kDa; CD44, CD44 molecule (Indian blood group); CDH13, cadherin 13, H-cadherin (heart); VCAN (formerly CSPG2), versican; FCGR2A, Fc fragment of IgG, low affinity IIa, receptor (CD32); GSK3B, glycogen synthase kinase 3 beta; PCDH17, protocadherin 17; and TAF11, TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa].