GSK3B


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GSK3B

A gene on chromosome 3q13.3 that encodes a serine-threonine kinase of the glycogen synthase kinase subfamily, which is involved in glycogen metabolism, proliferation, motility, survival, neuronal development and body pattern formation.
 
Molecular pathology
GSK-3 plays a role in diabetes, cancer and neurologic disease—GSK3B polymorphisms are implicated in Parkinson disease; GSK3B overexpression may play a role in Alzheimer’s disease.
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cinnamon extract; DMEM, Dulbecco's modified Eagle's medium; GLUT, glucose transporter; GSK3B, glycogen synthase kinase 3 beta; GYS1, glycogen synthase 1; IGF, insulin-like growth factor; IGFR, insulin-like growth factor receptor; INS, insulin; INSR, insulin receptor; IRS, insulin receptor substrate; LEP, leptin; LEPR, leptin receptor; PIK3CB, phosphatidylinositol 3-kinase, catalytic, beta; PIK3R1, phosphatidylinositol 3-kinase, regulatory subunit 1; RPL32, ribosomal protein L32; SHC1, Src homology 2 domain-containing transforming protein 1; SOS1, Son of sevenless 1; TTP, tristetraprolin; ZFP36, zinc finger protein 36.
Nine candidates failed the initial criteria, such as assay length or unsuitable CpG site location for primer and probe placement [BCOR, BCL6 co-repressor; CAV1, caveolin 1, caveolae protein, 22kDa; CD44, CD44 molecule (Indian blood group); CDH13, cadherin 13, H-cadherin (heart); VCAN (formerly CSPG2), versican; FCGR2A, Fc fragment of IgG, low affinity IIa, receptor (CD32); GSK3B, glycogen synthase kinase 3 beta; PCDH17, protocadherin 17; and TAF11, TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa].