GSA


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GSA

GNAS

A locus on chromosome 20q13.3 that has a highly complex imprinted expression pattern, giving rise to maternally, paternally and biallelically expressed transcripts derived from four alternative promoters and 5' exons. Some transcripts have a differentially methylated region (DMR) at their 5' exons. This DMR is commonly found in imprinted genes and correlates with transcript expression; one transcript produced from this locus and the antisense transcript are paternally expressed, noncoding RNAs, which may regulate regional imprinting. Alternative splicing of downstream exons results in different forms of the stimulatory G-protein alpha subunit, a key component of the classical signal-transduction pathway linking receptor-ligand interactions to adenylyl cyclase activation and various cellular responses.

Molecular pathology
GNAS mutations have been linked to pseudohypoparathyroidism types 1a and 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone and pituitary tumours.

GSA

Gerontological Society of America.

GSA

general somatic afferent system of nerves.
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Wichita Southeast High School GSA, (316) 807-2271, psychsteve2@yahoo.
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GSA establishes long-term government wide contracts with commercial firms to provide access to commercial supplies and services that can be ordered directly from GSA Schedule contractors.
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General Services Administration's (GSA) citizen satisfaction scores, as reported in the 4th quarter 2006 release of the American Customer Satisfaction Index (ACSI) E-Government Satisfaction Index, reflect an overall increase and steady climb in customer satisfaction with its websites, GSA announced today.