HSP90B1

(redirected from GRP94)

HSP90B1

A gene on chromosome 12q24.2-q24.3 that encodes a molecular chaperone of the HSP 90 family which has ATPase activity and functions in the processing and transport of secreted proteins. HSP90B1 plays a role in endoplasmic reticulum associated degradation.
References in periodicals archive ?
who showed that HSPs, in particular GRP94, bind peptides that are immunogenic in vitro and in vivo .
Effect of laminarin on the expression of GRP78 and GRP94 in rat after unilateral ureteral obstruction.
Decreased protein and mRNA expression of ER stress proteins GRP78 and GRP94 in HepG2 cells over-expressing CYP2E1.
found that treatment of the cells with diatrizoate caused the expression of the chaperones GRP (Glucose regulated protein) 78 and GRP94 which act to protect the cell under conditions of stress.
LPG3 is one of the class II LPG genes that encodes the Leishmania homolog of the mammalian Endoplasmic Reticulum (ER) chaperone GRP94, which belongs to HSP90 family (6).
The critical role of LPG3, homolog of the mammalian ER chaperon GRP94, is restricted to the synthesis of glycoconjugates implicated in parasite virulence, including LPG (lipophosphoglycan) (6).
Primary antibodies specific for calpain 1, IRE1, GRP78, GRP94, PARP, pro-caspase 3, pro-caspase 9, pro-caspase 7 and 13-actin were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA).
ER stress is generally characterized by up-regulation of IRE1, GRP78, GRP94, calpain 1 and CHOP, and phosphorylation of eukaryotic initiation factor-2[gamma] (elF2[gamma]).
En celulas de neuroblastoma humano SH-SY5Y, la Tg fue capaz de aumentar la expresion de las proteinas GRP78 y GRP94 (marcadores de estres del RE), produciendo ademas la activacion de la caspasa 12, la caspasa 9 y la caspasa 3, la escision de PARP, la fragmentacion del ADN y la muerte celular (96).
Overexpression of GRP78 and GRP94 are markers for aggressive behavior and poor prognosis in gastric carcinomas.
The N-terminal fragment of GRP94 is sufficient for peptide presentation via professional antigen presenting cells.
It has also been demonstrated that there is a time and dose dependent accumulation of HSP72 and GRP94 stress proteins on mercury (II) exposure.