HSPA5

(redirected from GRP78)
Also found in: Acronyms.

HSPA5

A gene on chromosome 9q33.3 that encodes a member of the heat shock 70 (HSP70) family which is localised in the lumen of the endoplasmic reticulum, where it is involved in protein folding and assembly. 

Molecular pathology
HSPA5 is an autoantigen implicated in the pathogenesis of rheumatoid arthritis.
References in periodicals archive ?
2 RT-PCR results in controls and after pBOO for 7 and 14 days; 2a) TGF-B levels increased significantly after 14 days, but the decrease with MSC treatment was not statistically significant; 2b) HIF-1a; 2c) RhoA; and 2d) GRP78 levels increase significantly after 14 days pBOO and treatment with MSC results in a statistically significant reduction in levels.
The gene expression of GRP78, ATF6, and CHOP, the markers of ER stress, was upregulated only in the PA stimulation group compared to OA treatment group (Figure 3(a)).
In cells affected by cancer, viruses and bacteria the normal protein making processes are often hijacked to make harmful proteins, But using a combination of the drugs OSU-03012 (AR-12) and Viagra, Prof Dent and his team - which includes a number of Brits - found they could stop GRP78 and other chaperones from working, killing cancer cells by preventing them from making the proteins they need.
The critical role of GRP78 in physiologic and pathologic stress.
Ashok Saluja said that the study shows that although increased expression of GRP78 confers a survival advantage to the tumor cells, prolonged exposure to triptolide induces chronic ER stress, which eventually leads to cell death.
Both CRIPTO and GRP78 have been implicated in cancers, including breast cancer and lung cancers.
En celulas de neuroblastoma humano SH-SY5Y, la Tg fue capaz de aumentar la expresion de las proteinas GRP78 y GRP94 (marcadores de estres del RE), produciendo ademas la activacion de la caspasa 12, la caspasa 9 y la caspasa 3, la escision de PARP, la fragmentacion del ADN y la muerte celular (96).
Overexpression of GRP78 and GRP94 are markers for aggressive behavior and poor prognosis in gastric carcinomas.
TISSUE DRUG HSP72 HSC73 HSP75 GRP78 Liver CON 3760 2919 2948 3b.
AKT inhibition mitigates GRP78 (glucose-regulated protein) expression and contribution to chemoresistance in endometrial cancers.