GRIP1


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GRIP1

A gene on chromosome 12q13.13 that encodes a protein which is thought to play a role as a localized scaffold for assembling a multiprotein signalling complex and mediating trafficking of its binding partners at specific subcellular sites in neurons.
GRIP1 interacts with EFNB1, EFNB3, EPHA7, EPHB2, FRAS1, GRIA2, GRIA3, GRIPAP1/GRASP1, KIF5A, KIF5B, KIF5C, PLCD4, PPFIA1, PPFIA4, PRLHR, PTPRF, SLC30A9 and liprins-alpha. GRIP1 can form homomultimers or heteromultimers with GRIP2, and a ternary complex with GRIA2 and CSPG4. It interacts with ATAD1 in an ATP-dependent manner—ATAD1-catalysed ATP hydrolysis disrupts binding to ATAD1 and to GRIA2 and leads to AMPAR complex disassembly.
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In this study, a positional candidate gene analysis was performed to test whether GRIP1 in the support interval region can affect BFT traits.
We identified 8 putative nucleotide substitutions in GRIP1 in the exon regions using HiSeq2000 massively parallel sequencing technology (Supplementary Table S1).
Hence, we investigated the association between SNP markers within the exons of GRIP1 and BFT-related traits in pigs.