GRIA4

GRIA4

A gene on chromosome 11q22 that encodes a member of the excitatory neurotransmitter glutamate receptor family, which are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) and function as ligand-activated cation channels.

Molecular pathology
Weak data have linked GRIA4 mutations to schizophrenia.
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A recent study of OSCC tumors from German OSCC patients suggests that ALH1A2, OSR2, GATA4, GRIA4, and IRX4 gene transcription is regulated by gene-promoter hypermethylation, which in turn correlates with HPV status in OSCC tumors (22).
Topiramate ([up arrow]) GRIA4 and GRIA2 flop mRNA levels in GRIK3 in hippocampus OFC and GRIA3 flip and (Enoch et al.
29) A recent GWAS (30) found that a combination of 6 genetic mark-ers--NPAS3, XKR4, TNR, GRIA4, GFRA2, and NUDT9P1--predicted treatment response to iloperidone.