GRB7


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GRB7

A gene on chromosome 17q12 that encodes an adapter protein which interacts with the cytoplasmic domain of numerous downstream protein kinases (e.g., STAT3, AKT1, MAPK1 and/or MAPK3), activating them. GRB7 promotes activation of HRAS; it plays a role in signal transduction in response to EGF and in regulating cell proliferation and cell migration. It also plays a role in the assembly and stability of RNA stress granules, binding target mRNA molecules and repressing their translation when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery from cellular stress.
References in periodicals archive ?
Nine of the Oncotype DX gene primer sets (for BAG1, CCNB1, SCUBE2, GRB7, ERBB2, MK167, MYBL2, PGR, and TFRC genes) span intron sequences and so do not detect genomic DNA; the 12 remaining Oncotype DX genes were tested for sensitivity to genomic DNA added into an FPET RNA pool.
T]SL2, cathepsin L2; ESR1, estrogen receptor 1; GRB7, growth factor receptor-bound protein 7; GSTM1, glutathione S-transferase M1; ERBB2, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian); MKI67, antigen identified by monoclonal antibody Ki-67; MYBL2, v-myb myeloblastosis viral oncogene homolog (avian)-like 2; PGR, progesterone receptor; AURKA, aurora kinase A; MMP11, matrix metallopeptidase 11 (stromelysin 3); BIRC5, baculoviral IAP repeat-containing 5 (survivin); ACTB, actin, beta; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GUSB, glucuronidase, beta; KPLPO, ribosomal protein, large, P0; TFRC, transferrin receptor (p90, CD71).
Expression of HER2 and the coamplified genes GRB7 and MLN64 in human breast cancer: quantitative realtime reverse transcription-PCR as a diagnostic alternative to immunohistochemistry and fluorescence in situ hybridization.
While the majority of these 16 genes were found to be estrogen receptor-related (ESR1, PGR, BCL2, SCUBE2) and proliferation-related (Ki67, STK15, Survivin, CCNB1, MYBL2), some genes did not belong to these 2 categories (HER2, GRB7, MMP11, CTSL2, GSTM1, CD68, BACG1).