GRB7


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GRB7

A gene on chromosome 17q12 that encodes an adapter protein which interacts with the cytoplasmic domain of numerous downstream protein kinases (e.g., STAT3, AKT1, MAPK1 and/or MAPK3), activating them. GRB7 promotes activation of HRAS; it plays a role in signal transduction in response to EGF and in regulating cell proliferation and cell migration. It also plays a role in the assembly and stability of RNA stress granules, binding target mRNA molecules and repressing their translation when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery from cellular stress.
References in periodicals archive ?
While the majority of these 16 genes were found to be estrogen receptor-related (ESR1, PGR, BCL2, SCUBE2) and proliferation-related (Ki67, STK15, Survivin, CCNB1, MYBL2), some genes did not belong to these 2 categories (HER2, GRB7, MMP11, CTSL2, GSTM1, CD68, BACG1).
a) Common Sequence ID Official gene gene name symbol BAG1 NM_004323 BAG1 Bcl2 NM_000633 BCL2 CCNB1 NM_031966 CCNB1 CD68 NM_001251 CD68 CEGP1 NM_020974 SCUBE2 CTSL2 NM_001333 CTSL2 EstR1 NM_000125 ESR1 GRB7 NM_005310 GRB7 GSTM1 NM_000561 GSTM1 HER2 NM_004448 ERBB2 Ki-67 NM_002417 MKI67 MYBL2 NM_002466 MYBL2 PR NM_000926 PGR STK15 NM_003600 AURKA STMY3 NM_005940 MMP11 SURV NM_001168 BIRC5 -Actin NM_001101 ACTB GAPDH NM_002046 GAPDH GUS NM_000181 GUSB RPLPO NM_001002 RPLP0 TFRC NM_003234 TFRC (a) Genes annotated with NCBI LocusLink sequence identification numbers and official gene symbols of the HUGO Gene Nomenclature Committee (http://www.
Nine of the Oncotype DX gene primer sets (for BAG1, CCNB1, SCUBE2, GRB7, ERBB2, MK167, MYBL2, PGR, and TFRC genes) span intron sequences and so do not detect genomic DNA; the 12 remaining Oncotype DX genes were tested for sensitivity to genomic DNA added into an FPET RNA pool.