GRB2


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GRB2

A gene on chromosome 17q24-q25 that encodes an adaptor protein which provides a critical link between cell surface growth factor receptors and the Ras-signalling pathway, and may play a role in apoptosis.
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2002) Grb2 is a key mediator of helicobacter pylori CagA protein activities.
Host cell molecules that interact with CagA Name of Molecule Binding site on Pathobiological effect of CagA the interaction ASPP2 Domain I Degradation and inactivation of p53 RUNX3 Domain I Degradation and inactivation of RUNX3 Phosphatidylserine Domain II CagA delivery, (PS) (basic patch) Membrane tethering of CagA O1-Integrin Domain II CagA delivery, Stimulation of SFKs and FAK C-terminal Src EPIpYA-A Aberrant activation kinase (CSK) EPIpYA-B of CSK, Inhibition of SFK activity PI3K EPIpYA-B Deregulation of the PI3K-AKT pathway SHP2 EPIpYA-C Deregulation of the EPIpYA-D Ras-ERK pathway, Inhibition of FAK Grb2 EPIYA?
Grb2 and thrombospondin 1, were regulated in NG-treated platelets.
The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling.
There were 25-, 22-, and 18-fold downregulation for GRB2, EGFR, and PTPN11 in the IMB from Tibetans when compared with Han Chinese.
GRB2, EGFR, and PTPN11 had similar expressing profiles with those obtained from the RNA transcriptomes analysis.
These ALK interacting molecules modulate protein phosphatases, upregulate downstream targets of the mTOR pathway that are involved in ribosome biosynthesis and translation (ribosomal S6 kinase, translational initiation factor elF4, ribosomal protein L11, eukaryotic translation initiation factor 3, translation initiation factor IF-2 homolog, and translation initiation factor elF-2[alpha]), and regulate cytoskelet al molecules such as the focal adhesion protein paxillin as well as the adaptor scaffold GRB2.
1998), or other adaptor molecules such as SH2-B, Grb2 or CrkII (VanderKuur et al.
Growth hormone-promoted tyrosyl phosphorylation of SHC proteins and SHC association with Grb2.
To address this challenge, the Lunenfeld collaborated with AB SCIEX scientists to utilize the AB SCIEX QTRAP 5500 System coupled to an Eksigent NanoLC Ultra + cHiPLC nanoflex liquid chromatography system to design a new approach, which the Canadian researchers used to investigate changes in protein interactions with the adaptor protein GRB2, an important hub in growth factor signaling.
Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signaling.
Nasdaq: SUGN) today announced that Company researchers have identified a novel class of signal transduction inhibitors that block the function of the GRB2 adapter protein.