GRB2


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GRB2

A gene on chromosome 17q24-q25 that encodes an adaptor protein which provides a critical link between cell surface growth factor receptors and the Ras-signalling pathway, and may play a role in apoptosis.
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The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling.
1998), or other adaptor molecules such as SH2-B, Grb2 or CrkII (VanderKuur et al.
Growth hormone-promoted tyrosyl phosphorylation of SHC proteins and SHC association with Grb2.
When an RTK is activated by the binding of specific growth factors, it conveys a biochemical "message" to nearby proteins, which in turn activate the ras pathway through GRB2.
SUGEN's R&D teams simulated the effect of GRB2 inhibition by the application of genetically engineered models, termed "dominant negatives".
To address this challenge, the Lunenfeld collaborated with AB SCIEX scientists to utilize the AB SCIEX QTRAP 5500 System coupled to an Eksigent NanoLC Ultra + cHiPLC nanoflex liquid chromatography system to design a new approach, which the Canadian researchers used to investigate changes in protein interactions with the adaptor protein GRB2, an important hub in growth factor signaling.