GRB14

GRB14

A gene on chromosome 2q22-q24 that encodes an adapter protein which interacts with insulin receptors and insulin-like growth factor receptors, downregulating tyrosine kinase receptor signalling and insulin receptor signalling. GRB14 is thought to play a role in signalling pathways that regulate growth and metabolism.
References in periodicals archive ?
In human and mammals, GRB14 mRNA was found to be expressed at high level in the ovary, liver, kidney, skeletal muscle and so on although the function of GRB14 in chicken is undefined, it may combine with the insulin-like growth factor system to influence egg production in layers.