GPR84

GPR84

A gene on chromosome 12q13.13 that encodes a G protein-coupled receptor for medium-chain free fatty acids (MCFFAs) with carbon chain lengths of C9 to C14—e.g., capric acid (C10), undecanoic acid (C11) and lauric acid (C12). Activation by MCFFAs is coupled to a pertussis-toxin-sensitive G(i/o) protein pathway. GPR84 plays roles in FFA metabolism and in regulating the immune system.
References in periodicals archive ?
GPR40 and GPR84 are known to be involved in diverse physiological processes related to metabolic regulation and to inflammation, but the fundamental importance of these receptors in the fibrosis pathways had not been recognized until now.
GLPG1205, which isA is fully proprietary to Galapagos, inhibits GPR84 and forms a potential novel treatment for inflammatory bowel diseases.
SeeNews) - Dec 16, 2014 - Belgian biotechnology firm Galapagos (AMS:GLPG) said Tuesday it had signed an agreement with Janssen Pharmaceutica to regain full rights to the entire GPR84 programme, including the inhibitor GLPG1205 and the backup compound GLPG2196.