GPR84

GPR84

A gene on chromosome 12q13.13 that encodes a G protein-coupled receptor for medium-chain free fatty acids (MCFFAs) with carbon chain lengths of C9 to C14—e.g., capric acid (C10), undecanoic acid (C11) and lauric acid (C12). Activation by MCFFAs is coupled to a pertussis-toxin-sensitive G(i/o) protein pathway. GPR84 plays roles in FFA metabolism and in regulating the immune system.
References in periodicals archive ?
GLPG1205, which isA is fully proprietary to Galapagos, inhibits GPR84 and forms a potential novel treatment for inflammatory bowel diseases.
SeeNews) - Dec 16, 2014 - Belgian biotechnology firm Galapagos (AMS:GLPG) said Tuesday it had signed an agreement with Janssen Pharmaceutica to regain full rights to the entire GPR84 programme, including the inhibitor GLPG1205 and the backup compound GLPG2196.