HCAR1

(redirected from GPR81)

HCAR1

A gene on chromosome 12q24.31 that encodes a G protein-coupled receptor for L-lactate, which mediates its anti-lipolytic effect via a G(i)-protein-mediated pathway.
References in periodicals archive ?
Collaboration with Zhejiang University Janssen Research & Development and Johnson & Johnson Innovation have established an R&D collaboration with Zhejiang University to elucidate the physiological and pathological role of human lactate receptor GPR81 in the regulation of metabolism and metabolic syndrome such as dyslipidemia, obesity, and diabetes.
Lactate inhibits lipolysis in fat cells through activation of an orphan g-protein-coupled receptor, GPR81.
Interestingly, a lactate receptor called GPR81 was recently isolated in rats, confirming that it does indeed act like a hormone.