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In conclusion, the novel phloroglucinol derivative BFP-induced human glioma cell death is mediated by ROS generation, which subsequently induces GPR78 and CHOP expression, increases caspases activity, such as caspase-9 and caspase-3, resulting in apoptosis.
Omeros announced that it has identified compounds that functionally interact selectively with each of four additional orphan G protein-coupled receptors (GPCRs) - GPR15, GPR39, GPR78 and GPR161.
13, 2011 /PRNewswire/ -- Omeros Corporation (NASDAQ: OMER) today reported that it has identified compounds that interact selectively with each of four additional orphan G protein-coupled receptors (GPCRs) - GPR15, GPR39, GPR78 and GPR161.
GPR78 has been linked to bipolar affective disorder and schizophrenia, and GPR161 has been tied to congenital cataracts and birth defects of the brain and spinal cord.
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