NMUR1

(redirected from GPR66)

NMUR1

A gene on chromosome 2q37.1 that encodes a neuromedin U (NMU) receptor of the Gq/11-protein-coupled receptor family, which is expressed in the periphery—especially in the GI tract. NMU receptors mediate various biological effects, including uterine contraction, vasoconstriction and activation of the hypothalamic-pituitary-adrenal (HPA) axis, resulting in decreased food intake via the corticotropin releasing hormone (CRH) system.
References in periodicals archive ?
Two different receptors exist for NmU, termed NMUR1 (also known as GPR66 and FM-3) and NMUR2 (also known as TGR-1 and FM-4), encoded by genes located in human chromosomes 2 and 5, respectively (14, 28, 29, 35-39).
Purification and identification of neuromedin U as an endogenous ligand for an orphan receptor GPR66 (FM3).