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In the INMA cohort, TPO and GPR55 were also significantly differentially expressed in relation to current N[O.
7 kbp downstream of GPR55 appeared to be FDR-significant after cell-type adjustment (according to the Houseman method).
McCormick added that they have found that these effects are mediated via the joint interaction of CB2 and GPR55 - two members of the cannabinoid receptor family and their findings help explain some of the well-known but still poorly understood effects of THC at low and high doses on tumour growth.
CBI and CB2 receptors and the novel cannabinoid receptor GPR55 has been found to be expressed in the [beta]-cells in murine islets and MINE cell line (Li et al.
Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands.
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