KISS1R

(redirected from GPR54)

KISS1R

A gene on chromosome 19p13.3 that encodes a Gq/G11 protein-coupled receptor that signals by stimulating phospholipase C, resulting in Ca2+ mobilisation. KISS1R is highly expressed in the pancreas, placenta and brain, and slightly expressed in the small intestine, kidney, lung, liver and heart. It plays a key role in the neuroendocrine control of the gonadotrophin axis and may inhibit metastases.
References in periodicals archive ?
Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54.
Characterization of the potent luteinizing hormone-releasing activity of KiSS-1 peptide, the natural ligand of GPR54.
Popa SM, Clifton DK, Steiner RA (2008) The Role of Kisspeptins and GPR54 in the Neuroendocrine Regulation of Reproduction.
The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54.
Thirty days later blood serum and hypothalamus of all the animals were obtained to determine secretion level of LH insulin leptin and expression of KiSS-1 and GPR54.
A kisspeptina atua via receptor GPR54 e parece estabelecer uma ligacao direta entre sinalizadores perifericos, como, por exemplo, esteroides gonadais e leptina, e a sintese de GnRH (GOTTSCH et al.
Kisspeptin is a newly discovered protein encoded by the KiSS-1 gene and is a ligand for the G protein-coupled receptor GPR54 [13].
Kisspeptin is a newly discovered protein which encodes by the KiSS-1 gene and is a ligand for the G protein-coupled receptor GPR54 (Pompolo et al.
Ese gene es la proteina GPR54, responsable de retardar o acelerar los cambios que se producen en la pubertad.
GPR54 and its ligand metastin, prokineticin 2 and its receptor, and the FGFR1 signaling pathway are all critical elements for GnRH neuron integrity in humans discovered using these approaches.