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However, the GPR54 and gonadotropin-releasing hormone 1 (GNRH1) gene expression were not influenced (p>0.
However, GPR54 and GNRH1 were not affected in the present study.
GPR54 and KISS1 (Dedes 2012)], or suggested by a previous study of dioxin-related genes and reproductive abnormalities (Sone and Yonemoto 2008).
2009 GPR54 3 2 Genes associated with reproductive outcomes KISS1 8 4 (puberty-related) Total 480 337 GWAS, genome-wide association studies.
Kisspeptin is a newly discovered protein encoded by the KiSS-1 gene and is a ligand for the G protein-coupled receptor GPR54 .
GPR54 and its ligand metastin, prokineticin 2 and its receptor, and the FGFR1 signaling pathway are all critical elements for GnRH neuron integrity in humans discovered using these approaches.
Synthetic Peptide to Antagonize GPR54 for Womens Health, Male Health and Oncology
Several mature peptides encoded by kiss-1 gene including kisspeptin-54, -14, -13 and -10, all of their carboxyl terminus is a motif of arginine-phenylalanine-NH2 (RF-NH2), and each can activate GPR54 with equal biopotency (Kotani et al.
1556) hypothesized that effects of EDCs on reproductive outcomes may result from effects on hypothalamo-pituitary-gonadal axis regulation by the kisspeptin (Kisspeptin-1) neuropeptide and its receptor, GPR54 (G-protein-coupled receptor 54).
Kisspeptins are peptide products of the KiSS-1 metastasis-suppressor (KISS1) gene and the natural ligands of the G-protein-coupled receptor GPR54.
With a motif of arginine phenylalanine-NH2 (RF-NH2) at the carboxyl terminus, each peptide can activate GPR54 with equal biopotency (Kotani et al.
METHODS: KiSS-1, GPR54, and ER[alpha] (estrogen receptor [alpha]) mRNA expression was quantified in control (C) and treated (T) maternal and fetal (110-day) hypothalami and pituitary glands using semiquantitative reverse transcription polymerase chain reaction, and colocalization of kisspeptin with LH[beta] (luteinizing hormone [beta]) and ER[alpha] in C and T fetal pituitary glands quantified using dual-labeling immunohistochemistry.
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