FFAR2

(redirected from GPR43)

FFAR2

A gene on chromosome 19q13.1 that encodes a member of the GP40 family of G protein-coupled receptors that is a receptor for short-chain free fatty acids. FFAR2 may be involved in the inflammatory response and in regulating lipid plasma levels.
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Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43.
Se sugiere que los AGCC son productos bacterianos claves para promover la integridad intestinal, aunque no es claro si este efecto se da por la inhibicion de la histona deacetilasas (HDACs, por la sigla en ingles de histone deacetylases) o por la estimulacion de receptores acoplados de la proteina-G (GPCRs, de su sigla en ingles G-protein-coupled receptors) GPR41, GPR43 o GPR109 (32).
In addition to being energy sources, SCFAs control colonic gene expression by inhibiting the enzyme HDAC and metabolic regulation by signaling through G-protein-coupled receptors, such as GPR41 and GPR43 (Tremaroli and Backhed 2012).
M2 PHARMA-December 21, 2011-Galapagos advances GPR43 inhibitor into Phase I development(C)2011 M2 COMMUNICATIONS
Plant-based foods such as dried fruit and beans convert to short chain fatty acids, which bind to GPR43 - a molecule released by immune cells - in the intestine and act as an anti-inflammatory agent, press tv reported.
Receptores membranales del tipo serpentina asociados a sistemas de proteinas G trimerico GPR (del ingles G protein-coupled receptor) como GPR40 (acidos grasos de cadena media), GPR41 (acidos grasos de cadena corta), GPR43 (acidos grasos de cadena corta) y GPR120 (acidos grasos de cadena larga).
Such patents include CCR5, ChemR23, GPR43, GPR7/8, purinergic receptors (P2Y4, P2Y11 and P2Y13) and SHIP2 for type II diabetes.
In response to activation by volatile fatty acids, GPR43 activates cellular responses that subsequently depress triacylglycerol turnover (Hardie, 2007), thereby promoting adiposity.
AMPKalpha, C/EBPbeta, CPT1beta, GPR43, PPARgamma, and SCD gene expression in single- and co-cultured bovine satellite cells and intramuscular preadipocytes treated with palmitic, stearic, oleic, and linoleic acid.
Quantitative real time polymerase chain reaction (qRT-PCR) was used to analyze the expression of C/EBP[beta], CPT1[beta], GPR43, PPAR[gamma], AMPK-[alpha], and SCD (primers listed in Table 1).
GPR43 is one of the GPCRs which coupled to both Gq and Gi/Go proteins.