FFAR2

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FFAR2

A gene on chromosome 19q13.1 that encodes a member of the GP40 family of G protein-coupled receptors that is a receptor for short-chain free fatty acids. FFAR2 may be involved in the inflammatory response and in regulating lipid plasma levels.
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Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43.
In addition to being energy sources, SCFAs control colonic gene expression by inhibiting the enzyme HDAC and metabolic regulation by signaling through G-protein-coupled receptors, such as GPR41 and GPR43 (Tremaroli and Backhed 2012).
Quantitative real time polymerase chain reaction (qRT-PCR) was used to analyze the expression of C/EBP[beta], CPT1[beta], GPR43, PPAR[gamma], AMPK-[alpha], and SCD (primers listed in Table 1).
The mRNA levels for GPR43 did not differ between cell types (p = 0.
001) for AMPK[alpha], C/EBP[beta], GPR43, PPAR[gamma], and SCD gene expression (Table 2).
GLPG0974 is the first inhibitor of GPR43 to be evaluated clinically for the treatment of IBD; this program is currently in a Proof of Concept Phase 2 study.
Plant-based foods such as dried fruit and beans convert to short chain fatty acids, which bind to GPR43 - a molecule released by immune cells - in the intestine and act as an anti-inflammatory agent, press tv reported.
Such patents include CCR5, ChemR23, GPR43, GPR7/8, purinergic receptors (P2Y4, P2Y11 and P2Y13) and SHIP2 for type II diabetes.
GPR43 is one of the GPCRs which coupled to both Gq and Gi/Go proteins.
In this study, we examined the expression characteristic of GPR43 in different tissues and primary adipocytes of pig both in vitro and in vivo, and analyzed the correlation between GPR43 and lipid metabolism-related genes.
Since there was no pig GPR43 gene sequence available, we used human and mouse sequences as reference to design primers for amplification of pig GPR43 cDNA.
Such patents address targets such as CCR5, Chemerin receptor, GPR43, GPR7/8, purinergic receptors (P2Y4, P2Y11 and P2Y13) and SHIP2 for type II diabetes.