GPR4

GPR4

A gene on chromosome 19q13.3 that encodes a G protein-coupled, proton-sensing receptor.
References in periodicals archive ?
Drug profiles discussed in this report are ACP-01, belimumab, beperminogene perplasmid, CCX-168, gevokizumab, immune globulin (human), Monoclonal Antibodies to Antagonize GPR4 for Vascular Inflammation, PF-1355, rituximab biosimilar, Stempeucel, tocilizumab and Vascostem.
Recently, two G-protein-coupled receptors with a high affinity for LPC were identified: G2A, which is an immunoregulatory receptor (7), and GPR4, which is a receptor for LPC and sphingosylphosphorylcholine (8).
In summary, LPC has been shown to function as a signaling molecule that binds to the G-protein-coupled receptors G2A (7) and GPR4 (8).