GPR39

GPR39

A gene on chromosome 2q21-q22 that encodes a G protein-coupled receptor that activates a phosphatidylinositol-calcium second messenger system. GPR39 is involved in regulating body weight, GI motility, hormone secretion and apoptosis.
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GPR39 (zinc receptor) knockout mice exhibit depression-like behavior and CREB/BDNF down-regulation in the hippocampus.
El GHS-R es un receptor acoplado a proteinas G y es miembro de la familia de receptores de grelina la cual incluye receptores de neurotensina, motilina, neuromedina asi como el receptor GPR39 (GPR, por sus siglas en ingles G proteincoupled receptor 39).
Funciones de la obestatina y grelina en el organismo Aparato/sistema Funciones Obestatina Receptor GPR39 Aparato Hambre [flecha inferior]- gastrointestinal Motilidad intestinal [flecha inferior]- Vaciado gastrico [flecha inferior]- Peso corporal [flecha inferior]- Polipeptido pancreatico [flecha inferior] Secrecion de insulina [flecha superior] [flecha inferior]- Secrecion acida del - ?
Omeros Corporation (Nasdaq:OMER), a clinical-stage biopharmaceutical company, said on Tuesday that it has identified compounds that interact selectively with each of four additional orphan G protein-coupled receptors (GPCRs), namely GPR15, GPR39, GPR78 and GPR161.
GPR15 has been associated with rheumatoid arthritis and HIV-mediated enteropathy, GPR39 has been implicated in the pathogenesis of obesity-related type-2 diabetes and oesophageal squamous cell carcinoma, GPR78 has been linked to bipolar affective disorder and schizophrenia and GPR161 has been tied to congenital cataracts and birth defects of the brain and spinal cord.
Obestatin was suggested to bind to an orphan G-protein coupled receptor (GPCR), named GPR39 (Pan et al.
Expression of GPR39 has been found in a variety of rat tissues including hypothalamus, amygdala, cerebrum, cerebellum, testis and ovary (Zhang et al.
He is an author of over 250 scientific publications, with recent important publications on GPCR molecule activation and on the role of GPR39, an important GPCR thought to be involved in regulating metabolic function.