GPR31

GPR31

A gene on chromosome 6q27 that encodes a G protein-coupled protein which is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE), an arachidonic acid metabolite secreted by platelets and tumour cells; HETE induces endothelial cell retraction, allowing invasive cell access to the subendothelial matrix, a critical step for extravasation or metastasis. GPR31 might be a chemoattractant receptor.
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Omeros Corporation (Nasdaq:OMER), a clinical-stage biopharmaceutical company, said on Wednesday that with its identification of compounds that interact selectively with each of four additional orphan G protein-coupled receptors (GPCRs), namely GPR19, GPR20, GPR31 and GPR141, it has now unlocked over 20% of the 77 Class A orphans.