GPR31

GPR31

A gene on chromosome 6q27 that encodes a G protein-coupled protein which is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE), an arachidonic acid metabolite secreted by platelets and tumour cells; HETE induces endothelial cell retraction, allowing invasive cell access to the subendothelial matrix, a critical step for extravasation or metastasis. GPR31 might be a chemoattractant receptor.
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These 23 orphans - CCRL2, GPR17, GPR19, GPR20, GPR21, GPR25, GPR31, GPR32, GPR50, GPR52, GPR80, GPR83, GPR135, GPR141, GPR150, GPR151, GPR153, GPR183 LGR4, LGR6, MAS1, OGR1 and OPN5 - are linked to a series of important indications, including melanoma, ovarian and prostate cancer, hepatocellular carcinoma, multiple sclerosis, anxiety disorders, schizophrenia, memory and emotion control, cognition, suspended animation, arterial stiffness, acute inflammatory responses, humoral immunity, bone disorders and wound repair.
These 19 orphans - CCRL2, GPR17, GPR19, GPR20, GPR21, GPR25, GPR31, GPR32, GPR50, GPR52, GPR80, GPR135, GPR141, GPR153, LGR4, LGR6, MAS1, OGR1 and OPN5 - are linked to a series of important indications, including melanoma, ovarian and prostate cancer, hepatocellular carcinoma, multiple sclerosis, anxiety disorders, schizophrenia, suspended animation, arterial stiffness, acute inflammatory responses, bone disorders and wound repair.
30, 2011 /PRNewswire/ -- Omeros Corporation (NASDAQ: OMER) today reported that with its identification of compounds that interact selectively with each of four additional orphan G protein-coupled receptors (GPCRs) - GPR19, GPR20, GPR31 and GPR141 - it has now unlocked over 20 percent of the 77 Class A orphans.
GPR31 has been implicated in anxiety disorders, which affect approximately 40 million adults in the United States in a given year.