GPR19

GPR19

A gene on chromosome 12p12.3 that encodes an orphan G protein-coupled receptor.
References in periodicals archive ?
GPR19 has been tied to metastatic melanoma, the most advanced stage of melanoma.
These statements include, but are not limited to, statements regarding Omeros' expectations regarding its ability unlock orphan GPCRs and add a large number of new drug targets and their corresponding compounds to the market; the disorders that could potentially be treated by drugs that target unlocked orphan receptors, including GPR19, GPR20, GPR31 and GPR141; the pharmaceutical industry's ability to design of proprietary compounds that interact with these receptors; and Omeros' intellectual property strategy around unlocked orphans and the breadth of protection Omeros may be able to obtain for each target.
These 19 orphans - CCRL2, GPR17, GPR19, GPR20, GPR21, GPR25, GPR31, GPR32, GPR50, GPR52, GPR80, GPR135, GPR141, GPR153, LGR4, LGR6, MAS1, OGR1 and OPN5 - are linked to a series of important indications, including melanoma, ovarian and prostate cancer, hepatocellular carcinoma, multiple sclerosis, anxiety disorders, schizophrenia, suspended animation, arterial stiffness, acute inflammatory responses, bone disorders and wound repair.
These 23 orphans - CCRL2, GPR17, GPR19, GPR20, GPR21, GPR25, GPR31, GPR32, GPR50, GPR52, GPR80, GPR83, GPR135, GPR141, GPR150, GPR151, GPR153, GPR183 LGR4, LGR6, MAS1, OGR1 and OPN5 - are linked to a series of important indications, including melanoma, ovarian and prostate cancer, hepatocellular carcinoma, multiple sclerosis, anxiety disorders, schizophrenia, memory and emotion control, cognition, suspended animation, arterial stiffness, acute inflammatory responses, humoral immunity, bone disorders and wound repair.