GPR17

GPR17

A gene on chromosome 2q21 that encodes a dual-specificity G protein-coupled receptor for uracil nucleotides, which may mediate brain damage by nucleotides and CysLTs following ischaemia.
References in periodicals archive ?
CNS remyelination as a novel reparative approach to neurodegenerative diseases: The roles of purinergic signaling and the P2Y-like receptor GPR17.
The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair," PLoS ONE, vol.
Inflammation increases GPR17, and higher levels are apparent in damaged MS tissue.
The next phase is to find an effective method of disabling GPR17, which may stimulate repair activity.