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The mitogenic effect of U-II is mediated by its receptor GPR14 (G-protein coupled receptor 14) and hence it can be inhibited by GPR14 antagonist .
Effects of urantide on the gene and protein expression of U-II and GPR14 in vascular smooth muscle cells
qRT-PCR and Western blot analysis were used to detect the gene and protein expression of U-II and GPR14 in vascular smooth muscle cells.
Effects of urantide on U-II and GPR14 mRNA expression in vascular smooth muscle cells
In group M, the expression of U-II and GPR14 mRNA dramatically increased compared with group C (p<0.
Effects of urantide on protein expression of U-II and GPR14 in vascular smooth muscle cells
In urantide-treated group, the protein expression of U-II and GPR14 were dramatically inhibited by urantide at different concentrations (p <0.
The receptor GPR14 is a specific U-II receptor in human body, mainly expressed in vascular and cardiac tissue .
We have investigated the effects and mechanisms and the receptor antagonist urantide of urotensin II (U-II) on the expression of U-II and its receptor GPR14 in rat vascular smooth muscle cells.
Increased expression of urotensin II and its cognate receptor GPR14 in atherosclerotic lesions of the human aorta.
In the course of its research SmithKline attempted to identify the human hormone that interacts with GPR14.
A team of scientists at the University of California at Irvine has also shown that urotensin-II binds to the GPR14 receptor.
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