O3FAR1

(redirected from GPR120)

O3FAR1

A gene on chromosome 10q23.33 that encodes a member of the rhodopsin family of G protein-coupled receptors that is a receptor for medium- and long-chain free fatty acids. O3FAR1 mediates a robust anti-inflammatory response, especially in macrophages and fat cells, by inhibiting TAK1 through a beta-arrestin 2 (ARRB2/TAB1)-dependent effect but independent of the G(q)/G(11)-coupled pathway. O3FAR1 mediates potent insulin-sensitising and antidiabetic effects by repressing macrophage-induced tissue inflammation.
References in periodicals archive ?
GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects.
Postprandial inhibition of gastric ghrelin secretion by long-chain fatty acid through GPR120 in isolated gastric ghrelin cells and mice.
The gene, called GPR120, can also cause fatty liver if it mutates, because in such a case, the organ's ability to burn fat diminishes.
The international team gave fatty feed to two groups of mice -- one in which the GPR120 gene was deactivated and the other in which it was left active.
The research also showed that the mice with deactivated GPR120 gene exhibited symptoms of fatty liver and diabetes.
The protein GPR120 is found on the surface of cells in the gut, liver and fat tissue and allows cells to detect and respond to unsaturated fatty acids from the diet, especially the omega-3 fatty acids which are believed to have a beneficial impact on health.
The researchers analyzed the gene for GPR120 in 6,942 obese people and 7,654 controls to test whether differences in the code that carries instructions for making the protein contribute to obesity in humans.
Recent research has also demonstrated that omega-3 fatty acids may exert a direct anti-inflammatory effect by interacting with a receptor located on fat cells known as GPR120.
Other Drugs Augmenting GLP-1 Secretion: GPR40, GPR120 & TGR5 Agonists
lt; < Family Receptor Type GPCRs < < GPR GPR120 < < Protease Activ- PAR4 < < Lysophospholip- S1P2 (Edg5) < < Urotensin rUT < < Serotonin 5-HT3A < < Glucagon GLP-2 < < Prokineticin PKR2 < < GPR GPR91 < < Glucagon Secretin < < Dopamine D2L < < Purinergic P2Y11 < < GPR GPR1 < < NeuropeptideFF NPFF1 Ion channels < < Voltage gated Kv1.
The receptor, known as GPR120, is located on macrophages in fat cells, and, when activated, prevents the macrophages from causing inflammation.
Olefsky and colleagues eventually narrowed their focus to a G-protein receptor called GPR120, which is found only on pro-inflammatory macrophages in mature fat cells.