GP1BA

(redirected from GPIbA)

GP1BA

A gene on chromosome 17pter-p12 that encodes the alpha subunit of the Ib-V-IX system of platelet surface membrane glycoproteins, which comprise the von Willebrand factor (vWF) receptor and mediate adhesion of platelets to injured vascular surfaces with circulation, a critical event in haemostasis. The alpha subunit provides the vWF binding site.

Molecular pathology
GP1BA polymorphisms and mutations are linked to Bernard-Soulier syndromes and platelet-type von Willebrand disease.
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References in periodicals archive ?
Most of the genetic defects are due to mutations of the GPIba gene, but may also be due to defects of the GPIbI3 or GPIX genes.
Platelet treatment with mocarhagin, a cobra venom metalloproteinase that cleaves GpIba, significantly reduced aggregation induced by 5 mM without affecting the response to other agonists such as adenosine diphosphate (ADP).
To verify this hypothesis, we performed a platelet treatment with the cobra venom metalloprotease mocarhagin, which cleaves GpIba.